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Torres, Gonzalo E.,Yao, Wei-Dong,Mohn, Amy R.,Quan, Hui,Kim, Kyeong-Man,Levey, Allan I.,Staudinger, Jeff,Caron, Marc G. 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-
PDZ domain-containing proteins play an important role in the targeting and localization of synaptic membrane proteins. Here, we report an interaction between the PDZ domain-containing protein PICK1 and monoamine neurotransmitter transporters in vitro and in vivo. In dopaminergic neurons, PICK1 colocalizes with the dopamine transporter (DAT) and forms a stable protein complex. Coexpression of PICK1 with DAT in mammalian cells and neurons in culture results in colocalization of the two proteins in a cluster pattern and an enhancement of DAT uptake activity through an increase in the number of plasma membrane DAT. Deletion of the PDZ binding site at the carboxyl terminus of DAT abolishes its association with PICK1 and impairs the localization of the transporter in neurons. These findings indicate a role for PDZ-mediated protein interactions in the localization, expression, and function of monoamine transporters.
Dopaminergic Supersensitivity in G Protein-Coupled Receptor Kinase 6-Deficient Mice
( Raul R. Gainetdinov ),( Laura M. Bohn ),( Tatyana D. Sotnikova ),( Michel Cyr ),( Aki Laakso ),( Alexander D. Macrae ),( Gonzalo E. Torres ),( Kyeong Man Kim ),( Robert J. Lefkowitz ),( Marc G. Caro 전남대학교 약품개발연구소 2003 약품개발연구지 Vol.12 No.-