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- 주제어 : anti-obesity therapeutic (검색결과 3 건)
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Aronia melanocarpa reduced adiposity via enhanced lipolysis in high-fat diet-induced obese mice
Kim, Hyun Kyung,Jung, Jiyeon,Kang, Eun Young,Gang, Gyoungok,Kim, Wooki,Go, Gwang-woong Korean Society of Food Science and Technology 2020 한국식품과학회지 Vol.52 No.3
Obesity is a critical health issue in Korea, where half of all adults are overweight and a third obese. Aronia melanocarpa -rich in flavonoids and phenolics- with antioxidant and anti-inflammatory activities, could have anti-obesity activity and reduce body fat mass by upregulating lipolysis and β-oxidation in obese mice. Male C57BL/6J mice (n=12) were assigned into four groups: normal chow (18% kcal from fat); high-fat diet control (HFD, 45% kcal from fat); HFD+A. melanocarpa (200 mg/kg diet); HFD+Xenical (500 mg/kg diet, positive control). Antioxidant capacity of A. melanocarpa was established in vitro and in vivo. Weight loss was induced as decreased adiposity and lowered respiratory quotient at rest suggested oxidation of stored fat. Adiposity reduction, accompanied with elevated fat utilization, was owing to enhanced activity of hormone-sensitive lipase. Thus, A. melanocarpa lowered adiposity by enhancing lipolysis and utilization of fatty acids in visceral fat.
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Aronia melanocarpa reduced adiposity via enhanced lipolysis in high-fat diet-induced obese mice
Hyun Kyung Kim,Jiyeon Jung,Eun Young Kang,Gyoungok Gang,Wooki Kim,고광웅 한국식품과학회 2020 한국식품과학회지 Vol.52 No.3
Obesity is a critical health issue in Korea, where half of all adults are overweight and a third obese. Aronia melanocarpa -rich in flavonoids and phenolics- with antioxidant and anti-inflammatory activities, could have anti-obesity activity and reduce body fat mass by upregulating lipolysis and β-oxidation in obese mice. Male C57BL/6J mice (n=12) were assigned into four groups: normal chow (18% kcal from fat); high-fat diet control (HFD, 45% kcal from fat); HFD +A. melanocarpa (200 mg/kg diet); HFD+Xenical (500 mg/kg diet, positive control). Antioxidant capacity of A. melanocarpa was established in vitro and in vivo. Weight loss was induced as decreased adiposity and lowered respiratory quotient at rest suggested oxidation of stored fat. Adiposity reduction, accompanied with elevated fat utilization, was owing to enhanced activity of hormone-sensitive lipase. Thus, A. melanocarpa lowered adiposity by enhancing lipolysis and utilization of fatty acids in visceral fat.
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하늘타리(Trichosanthes kirilowii Maxim.) 뿌리 에탄올 추출물의 3T3-L1 지방세포 분화 억제 융합연구
김성옥,정지숙 한국융합학회 2019 한국융합학회논문지 Vol.10 No.3
The ami of our study was on the anti-obesity effect of ethanol extract from Trichosanthes kirilowii Maxim root (TKM) in murine adipocytes, 3T3-L1 cells. This study focused on anti-adipogenic activity through inhibition of cell differentiation in 3T3-L1 cells treated TKM. 100 ug/ml of non-cytotoxic TEM remarkablely inhibited content of triglycerol and suppressed expressions of C/EBPα, PPARγa and SREBP-1c related with lipogenic transcription factors in theres 3T3-L1 cells compared to (-)control cells. As phosphorylations of AMPK and ACC were incerased, HSL and CPT-1 mRNA expression increased upon TKM treatment, which involved in inhibition of fatty acid synthase expression. In conclusion, these results indicate that TKM can inhibit mRNA and protein expression of lipogenic genes in 3T3-L1 adipocytes. Our study suggests that TKM has potential anti-obesity effects and is a convergence therapeutic functional agent with anti-adipogenic activity via hypolipogenesis. 본 연구는 3T3-L1 세포로 하늘타리(Trichosanthes kirilowii Maxim) 뿌리 에탄올 추출물(TKM)의 항비만 활성을 조사하였다. TKM 처리 한 3T3-L1 지방세포의 분화억제를 통한 지방생성 억제에 초점을 두었다. 세포독성을 나타내지 않는 100ug/ml 농도에서 TG 함량을 현저히 억제하고, 세포 초기분화 전사인자 PPARγ, C/EBPα, SREBP-1c의 발현 억제, 세포내 에너지 향상성 조절인자 pAMPK, 중성지방산의 합성분해 조절인자 pACC, CPT-1, 지방산 합성 효소(FAS) 발현 억제, 호르몬자극지방분해 효소(HSL) 활성화 등 지방합성 관련인자들의 발현 조절 효능이 있는 것으로 확인되었다. 이상의 결과로 TKM은 지방세포 분화와 지방대사 관련 인자들의 발현을 조절함으로써 지방 생성과 축적 저해 효능을 보여 항비만 융합치료제로의 가능성을 제시하였다.
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