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RISS 인기검색어
- 검색키워드
- 주제어 : Morinda tinctoria (검색결과 4 건)
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Joshua Sharon Nissi,Srinivasakumar Vyaishnavi,Ragu Sivaranjanee,Muthu Parkkavi Sekar,Dhakshinamoorthy Sundaramurthi,Vellingiri Vadivel 한국고분자학회 2023 Macromolecular Research Vol.31 No.4
As synthetic medications have various limitations and side effects in wound treatment, alternatively active wound dressing material could be designed by incorporating natural extracts. Electrospun fibers infused with plant extract can act as an active wound dressing material to speed up the process of wound healing. In this connection, the wound-healing efficacy of an Indian traditional drug Morinda tinctoria was reported earlier, but not yet explored as a natural active ingredient in electrospun fibers. The present work focused on preparing the extracts of M. tinctoria leaf and analyzing their yield, total phenolic concentration (TPC) and GC–MS phytochemical profile. The safety of methanol extract was studied in PBMC cells through MTT and live/dead assays and also TNF-α & IL-6 levels were quantified. Electrospinning of M. tinctoria-infused PHBV fiber mat was developed and characterized through SEM, FT-IR and TG–DTA. Results indicated that the methanol extract has a greater yield (2.47%) and TPC (4260.72 mg/L) when compared to other solvent extracts due to the presence of high polar molecules in M. tinctoria. GC–MS study revealed the phytochemicals such as coumarin and methylanthraquinone in the methanolic extract. MTT assay and live/dead staining revealed that the M. tinctoria extract was safe with 99% cell viability with intact cell wall. M. tinctoria induced the levels of TNF-α (328.75 pg/mL) and IL-6 (1357.14 pg/mL), which could improve the migration and proliferation of fibroblasts during wound healing. Development of M. tinctoria-infused fiber mat was optimized with 12% polymer concentration, 18 kV voltage, 0.01 mL/min flow rate and 14 cm tip to collector distance. SEM analysis of M. tinctoria-infused fiber mat revealed bead-less smooth fibers of 1.19 ± 0.15 μm diameter and 0.024 ± 0.003 μm pore size. FT-IR spectra revealed functional groups such as phenols, amines and alkanes in extractincorporated fibers. A drop in temperature (457 °C) was noticed in M. tinctoria-infused fiber mat when compared to the control (595 °C), which indicates the degradation of organic matters in the fiber mat. M. tinctoria-infused fiber mat could be applied as wound dressing material after conducting suitable animal experiments.
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Jaganathan Anitha,Rajendran Selvakumar,Senthilnayagam Hema,Kadarkarai Murugan,타탄프렘쿠마르 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.105 No.-
Zinc oxide nanoparticles (ZnO NPs) were prepared by a facile, one-pot, greener approach using aqueousleaf extract of the medicinal plant Nuna (Morinda tinctoria) and were analyzed by ultraviolet–visible (UV–Vis) and Fourier-transform infrared (FT-IR) spectroscopy, powder X-ray diffraction (PXRD), field emissionscanning electron microscopy (FESEM), and transmission electron microscopy (TEM) techniques. TheTEM images confirmed that the as-prepared greener Nuna (Nu)-mediated ZnO NPs (Nu-ZnO NPs) werespherical in shape, with an average diameter of 8–10 nm. Further, the single phase and crystallinity ofthe Nu-ZnO NPs were observed by PXRD pattern. In addition, the biogenic Nu-ZnO NPs showed high cytotoxicityin human breast adenocarcinoma (MCF-7) cells in vitro. These tiny spherical bodies producedprofound toxicity according to the MTT assay, with IC50 of 46 mg/mL. Apoptosis and morphologicalchanges were studied using acridine orange/ethidium bromide and 40,6-diamidino-2-phenylindole fluorescencestaining and MTT assays. Finally, the anticancer efficacy of biosynthesized Nu-ZnO NPs wasimparted by dysregulation of cell division through arrest of growth-promoting and inhibiting signalsin the S phase, with further reduction in the G2/M phase of the cell cycle. In conclusion, Nu-ZnO NPs conferredMCF-7 cell toxicity by modulating proliferation and inducing apoptosis.
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Phytochemical and therapeutic potentials of Morinda tinctoria Roxb. (Indian mulberry)
Atish K Sahoo,Nisha Narayanan,N Satheesh Kumar,S Rajan,Pulok K Mukherjee 경희대학교 융합한의과학연구소 2009 Oriental Pharmacy and Experimental Medicine Vol.9 No.2
Morinda tinctoria Roxb. (Family: Rubiaceae) is commonly known as Indian mulberry or Aal in India. This plant is very well known for its therapeutic benefit in Indian systems of medicine including Ayurveda and Siddha and in other forms of traditional Medicine worldwide for the treatment of several ailments. Almost all parts of this plant have been explored for its medicinal uses. Several reports on the phytochemical and therapeutic benefits of this plant have been reported. In this article an attempt has been made to review the traditional uses, phytochemical profiles and therapeutic potentials of Indian mulberry. Morinda tinctoria Roxb. (Family: Rubiaceae) is commonly known as Indian mulberry or Aal in India. This plant is very well known for its therapeutic benefit in Indian systems of medicine including Ayurveda and Siddha and in other forms of traditional Medicine worldwide for the treatment of several ailments. Almost all parts of this plant have been explored for its medicinal uses. Several reports on the phytochemical and therapeutic benefits of this plant have been reported. In this article an attempt has been made to review the traditional uses, phytochemical profiles and therapeutic potentials of Indian mulberry.
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Phytochemical and therapeutic potentials of Morinda tinctoria Roxb. (Indian mulberry)
Sahoo, Atish K,Narayanan, Nisha,Kumar, N Satheesh,Rajan, S,Mukherjee, Pulok K Kyung Hee Oriental Medicine Research Center 2009 Oriental pharmacy and experimental medicine Vol.9 No.2
Morinda tinctoria Roxb. (Family: Rubiaceae) is commonly known as Indian mulberry or Aal in India. This plant is very well known for its therapeutic benefit in Indian systems of medicine including Ayurveda and Siddha and in other forms of traditional Medicine worldwide for the treatment of several ailments. Almost all parts of this plant have been explored for its medicinal uses. Several reports on the phytochemical and therapeutic benefits of this plant have been reported. In this article an attempt has been made to review the traditional uses, phytochemical profiles and therapeutic potentials of Indian mulberry.
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