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RISS 인기검색어
- 검색키워드
- 주제어 : Carbopol 934P (검색결과 2 건)
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Kai Bin Liew,Kok Khiang Peh 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.8
Orally disintegrating tablet (ODT) is a userfriendly and convenient dosage form. The study aimed toinvestigate the effect of polymers and wheat starch on thetablet properties of lyophilized ODT, with dapoxetine asmodel drug. Three polymers (hydroxypropylmethyl cellulose,carbopol 934P and Eudragit EPO) and wheat starchwere used as matrix forming materials in preparation oflyophilized ODT. The polymeric dispersion was casted intoa mould and kept in a freezer at -20 C for 4 h beforefreeze dried for 12 h. It was found that increasing in HPMCand Carbopol 934P concentrations produced tablets withhigher hardness and longer disintegration time. In contrast,Eudragit EPO was unable to form tablet with sufficienthardness at various concentrations. Moreover, HPMCseems to have a stronger effect on tablet hardness comparedto Carbopol 934P at the same concentration level. ODT of less friable was obtained. Wheat starch acted asbinder which strengthen the hardness of ODTs and prolongedthe disintegration time. ODT comprising of HPMCand wheat starch at ratio of 2:1 was found to be optimumbased upon the tablet properties. The optimum formulationwas palatable and 80 % of the drug was released within30 min in the dissolution study.
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Imperatorin Sustained-release Tablets: In Vitro and Pharmacokinetic Studies
Jingjing Pan,Wen Lu,Changhui Li,Sicen Wang,Langchong He 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.8
We prepared and evaluated imperatorin (IMP) sustained-release tablets. IMP is an active compound in Angelica dahuricae, a Chinese herbal medicine. We used different polymers, such as hydroxypropyl methylcellulose (HPMC K4M, K15M, and K100M), carbopol 934P, sodium carboxymethyl cellulose (CMC-Na), and their combinations to prepare the matrix tablets and achieve the desired sustained release profile. The in vitro release profiles of these formulations were examined and fit to various kinetic release models. We also tested the effects of polymer combination ratios on the in vitro release rate. In vivo studies were performed for the optimized formulation in six beagle dogs, and pharmacokinetic parameters were compared with plain IMP tablets. IMP sustained-release tablets exhibited a more sustained plasma concentration than the plain tablets, with a relative bioavailability of 127.25%. The in vitro releases rates and in vivo absorption correlated for the initial 8 hours. These results demonstrate that the sustained-release tablet system can effectively control the release of IMP.
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