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고귀환(苦貴丸)과 오자환(五子丸) 추출물의 생리활성비교분석
황은희 ( Eun Hee Hwang ),권동렬 ( Dong Yeul Kwon ),정동명 ( Dong Myong Jeong ) 원광대학교 인체과학연구소 2008 원광인체과학회지 Vol.9 No.1
This study was performed to comparative analysis the biological activities of two kind health foods extracts. Studies on the antioxidative activities and effective extracting fraction of koguihwan and ojawhan extracts. These sample were carried out dried granule of health food were partitioned into the fractions of n-Hexane, Ethylacetate (EtOAc), n-Butanol (BuOH) and aqueous fractions, respectively. In Ojahwan extracts, the yield of the aqueous fraction was highest among those solvents, 77.7g (2.43w/v%) out of 3.2L of Ojahwan, and 141.7g (68.9%) out of 205.8g of Methanol (MeOH) fraction of Koguihwan. The 1,1-diphenyl-2-picryl hydrazyl (DPPH) free radical scavenging activity and lipid peroxidation inhibition activity, however, were best in EtOAc fraction. In the DPPH free radical scavenging activity, RC50 (㎍/ml) of EtOAc fraction of koguihwan extracts is 2 times and 14% of ojawhan extracts RC50 (㎍/ml) respectively, In the lipid peroxidation inhibition activity, RC50 (㎍/ml) of EtOAc fraction of koguihwan is 7 times and 3 times of ojawhan extracts RC50 (㎍/ml) respectively. From these results some fractions including EtOAc fraction of koguihwan is suggested to have high antioxidative activities.
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Zhang, Xiao Dan,Liu, Xiang Qian,Kim, Yang Hee,Whang, Wan Kyunn 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.5
The aim of this study was to investigate chemical constituents of the leaves of Acanthopanax henryi, and their antioxidant, acetyl cholinesterase inhibitory activities. Caffeoyl quinic acid derivates and flavonoids were obtained from A. henry, through column chromatography technologies, and the content of major constituents was determined by the HPLC-UV method. Anti-oxidant activity of the isolated metabolites was evaluated by free radical scavenging (DPPH, ABTS radicals) and superoxide anion scavenging. The results showed that di-caffeoyl quinic acid derivates had stronger antioxidant activity than positive controls (ascorbic acid, trolox and allopurinol). Acetyl cholinesterase inhibitory activity was estimated on the constituents, among which, quercetin, 4-caffeoyl-quinic acid and 4,5-caffeoyl quinic acid were found to have strong acetyl cholinesterase inhibitory activity with $IC_{50}$ values ranging from 62.6 to $121.9{\mu}M$. The present study showed that some of the tested constituents from the leaves of A. henryi exhibit strong antioxidant and acetyl cholinesterase inhibitory effects. This suggest that the leaves of A. henryi can be used as a new natural complementary source of acetyl cholinesterase inhibitors and anti-oxidant agents, thus being a promising potential complementary source against Alzheimer's disease.
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