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2-[(4-Cyanophenyl)amino]-3-chloro-1,4-naphthalenedione(NQ-Y15)의 돌연변이원성
김봉희,정기화,유충규,창동신,이기선,전선덕,소동수,채상호,문창규 한국환경독성학회 2000 환경독성보건학회지 Vol.15 No.4
2-[(4-Cyanophenyl)amino]-3-chloro-1, 4-naphthalenedione (NQ-Y15) was asssayed for its genotoxic potential by using Salmonella typhimurium reversion assay and in vitro chromosome aberration test on Chinese hamster lung cells. In the Ames test, NQ-Y 15 induced his+ revertants of Salmonella typhimurium TA 98 and TA1537, reaching levels twice the negative control values. But, NQ-Y15 induced only his^(+) revertants of Salmonella typhimurium TA1537 more than twice the control values under the condition with metabolic activation system. In the cytogenetic test on chinese hamster lung cells, NQ-Y15 showed significant chromosomal aberrations, but the incidence was significantly reduced in the presence of metabolic activation.
2- [4-cyanophenyl)amino)]-3-chIoro-1,4-naph thalened ione (NQ-Y15)가 마우스의 면역병리 및 체액성 면역에 미치는 영향
표명윤 숙명여자대학교 약학연구소 2002 약학논문집-숙명여자대학교 Vol.18 No.-
In order to investigate the effects of 2-[(4-cyanophenyl)amino]-3-chloro-l,4-naphthalenedione (NQ-Y15) on immune system in mice, we examined the immunopathological parameters and splenic IgM plaque forming cells (PFC) in this study. The immunopathological parameters (weights of body and organs, hematological parameters) were examined on day 1, 2,4 and 6 following single oral administration of NQ-Y15 (125, 250, 500 mg/kg) to female ICR mice. The weight of body was not changed. However, the weights of organs were slighty increased, and among hematological parameters WBC and platelet (PLT) were slightly changed in a dose- and test day-dependent manner when compared with control group. When NQ-Y15 was administered before immunization with SRBCantigen, PFC was significantly and dose-independently enhanced, but PFC was slightly decreased only at a high dose of NQ-Y15 when administered after antigenic challenge. These results indicate that the effects of NQ-Y15 on primary humoral immune response may be dependent on the timing of its administration relative to the initial antigenic challenge.
2-[(4-Cyanophenyl)amino]-3-chloro-1,4-naphthalenedione (NQ-Y15)의 돌연변이원성
김봉희,정기화,유충규,창동신,이기선,전선덕,소동수,채상호,문창규 德成女子大學校 藥學硏究所 2001 藥學論文誌 Vol.12 No.1
2-[(4-Cyanophenyl)amino]-3-chloro-1, 4-naphthalenedione (NQ-Y15) was asssayed for its genotoxic potential by using Salmonella typhimurium reversion assay and in vitro chromosome aberration test on Chinese hamster lung cells. In the Ames test, NQ-Y15 induced his+revertants of Salmonella typhimurium TA 98 and TA 1537, reaching levels twice the negative control values. But, NQ-Y15 induced only his+revertants of Salmonella typhimurium TA 1537 more than twice the control values under the condition with metabolic activation system. In the cytogenetic test on chinese hamster lung cells. NQ-Y15 showed significant chromosomal aberrations, but the incidence was significantly reduced in the presence of metabolic activation.