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生地黃의 Water Extrat가 Alloxan 負荷 생쥐 및 家兎의 血糖値에 미치는 影響
河春子 順天鄕大學校 1979 의대논문집 Vol.4 No.-
Alloxan monohydrate administered intravenously to mice and rabbits in doses of 50 or 100mg/Kg caused to be selectively taken up by the insulin-producing β-cell of the pancreas and elevation of the blood glucese levels. Water extract of Rehmanniae Rhizoma(RGLW) administered intraperitoneally or per oral 30 minutes prior to allovan prevented these diabetogenic actions. RGLW, a widly used crud drugs, was chosen because it decrease blood glucose. The data of the present study indicate that RGLW can protect against the diabetogenic action of alloxan.
生地黃 Water extract이 Catecholamines의 物質代謝作用에 미치는 影響
河春子 順天鄕大學校 1980 의대논문집 Vol.5 No.-
RRW, a widly used crud drugs, was chosen because it decrease blood glucose but not influence hyperglycemia of epinephrine. Influence of Rehmannial Rhizoma water Exract(RRW) on the metabolic effect of plasma glucose and free fatty acids to norepinephrine, epinephrine and isoproterenol was investigated in the rats. The following results were obtained; 1. Large dose of RRW(100mg/Kg) decreased blood glucose and free fatty acid, level, whereas Small dose of RR\(30mg/Kg) decreased only blood glucose level after 90min and free fatty acid level increased. 2. Hyper glycermia of Norepinephrine & epinephrine did not blocked by RRW but those of Isoprotenenol was blocked. 3. From these observation it is inferred that hypoglycemic effect of RRW did not blocked α-adrenergic receptor.