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Song, Dong Hyun,Kim, Won-Keun,Gu, Se Hun,Lee, Daesang,Kim, Jeong-Ah,No, Jin Sun,Lee, Seung-Ho,Wiley, Michael R.,Palacios, Gustavo,Song, Jin-Won Allen Press, etc 2017 The American journal of tropical medicine and hygi Vol.96 No.2
<P>Hantaan virus (HTNV), identified in the striped field mouse (Apodemus agrarius), belongs to the genus Hantavirus of the family Bunyaviridae and contains tripartite RNA genomes, small (S), medium (M), and large (L) segments. HTNV is a major causative for hemorrhagic fever with renal syndrome (HFRS) with fatality rates ranging from 1% to 15% in the Republic of Korea (ROK) and China. Defining of HTNV whole-genome sequences and isolation of the infectious particle play a critical role in the characterization and preventive and therapeutic strategies of hantavirus outbreaks. Next-generation sequencing (NGS) provides an advanced tool for massive genomic sequencing of viruses. However, the isolation of viral infectious particles is a huge obstacle to investigate and develop anti-virals for hantaviruses. Here, we report 12 HTNV isolates from lung tissues of the striped field mouse in the highly HFRS-endemic areas. Sequence-independent, single-primer amplification (SISPA) NGS was attempted to recover the genomic sequences of HTNV isolates. The nucleotide sequence of HTNV S, M, and L segments were covered up to 99.4-100%, 97.5-100%, and 95.6-99.8%, respectively, based on the full length of the prototype HTNV 76-118. The whole-genome sequencing of HTNV isolates was accomplished by additional reverse transcription polymerase chain reaction (RT-PCR) and rapid amplification cDNA ends (RACE) PCR. In conclusion, this study will lead to the attempt and usage of SISPA NGS technologies to delineate the whole-genome sequence of hantaviruses, providing a new era of viral genomics for the surveillance, trace, and disease risk management of HFRS incidents.</P>
Yoo, Jeong Rae,Heo, Sang Taek,Koh, Young-Sang,Kim, Sohyun,Kim, Seok Allen Press, etc 2014 The American journal of tropical medicine and hygi Vol.90 No.3
<P>We investigated the clinical characteristics and serologic types of tsutsugamushi disease on the largest island of South Korea. There were 141 patients with tsutsugamushi disease at Jeju National University Hospital and Seogwipo Medical Center between November of 2003 and December of 2012. Median age of patients was 61 years, and 59% were women. The major clinical manifestations were fever (80.5%) and skin rash (55.7%), with eschars evident in 75.8% of the patients. Genotype analysis of Orientia tsutsugamushi was conducted in 33 specimens. The genotype was identified as Boryong type in 17 of 33 patients and Taguchi type in 15 of 33 patients. In our study, although the Taguchi genotype is rarely reported in the endemic area, it was common on Jeju Island. This genotype may be associated with mild and moderate forms of tsutsugamushi disease.</P>
Desai, Sachin N.,Akalu, Zenebe,Teshome, Samuel,Teferi, Mekonnen,Yamuah, Lawrence,Kim, Deok Ryun,Yang, Jae Seung,Hussein, Jemal,Park, Ju Yeong,Jang, Mi Seon,Mesganaw, Chalachew,Taye, Hawult,Beyene, Dem Allen Press, etc 2015 The American journal of tropical medicine and hygi Vol.93 No.3
<P>Killed whole-cell oral cholera vaccine (OCV) has been a key component of a comprehensive package including water and sanitation measures for recent cholera epidemics. The vaccine, given in a two-dose regimen, has been evaluated in a large number of human volunteers in India, Vietnam, and Bangladesh, where it has demonstrated safety, immunogenicity, and clinical efficacy. We conducted a double-blind randomized placebo-controlled trial in Ethiopia, where we evaluated the safety and immunogenicity of the vaccine in 216 healthy adults and children. OCV was found to be safe and elicited a robust immunological response against <I>Vibrio cholerae</I> O1, with 81% adults and 77% children demonstrating seroconversion 14 days after the second dose of vaccine. This is the first study to evaluate safety and immunogenicity of the vaccine in a population outside Asia using a placebo-controlled, double-blind, randomized study design.</P>
Risk factors for Opisthorchis viverrini and minute intestinal fluke infections in Lao PDR, 2009-2011
Yoon, H.J.,Ki, M.,Eom, K.,Yong, T.-S.,Chai, J.-Y.,Min, D.-Y.,Rim, H.-J.,Sohn, W.-M.,Insisiengmay, B.,Phommasack, B. Allen Press, etc 2014 The American journal of tropical medicine and hygi Vol.91 No.2
Jung, Jongwoo,Jung, Yunjung,Min, Gi-Sik,Kim, Won Allen Press, etc 2007 The American journal of tropical medicine and hygi Vol.77 No.2
<P>The population genetics of Anopheles sinensis, a major malaria vector in South Korea, was studied based on the nucleotide sequences of a 238-bp variable region of the mitochondrial control region. Three features of genetic variance were observed. First, the Taebaek and Sobaek mountain ranges may function as genetic barriers between the Northern Group (NG) and the Southern Group (SG). These mountain ranges are associated with the subdivision of the population, and significant and unique population differentiation was observed in the examined area. Second, the genetic cohesiveness observed within each group may have been caused by a recent expansion in the population rather than recurrent gene flow. Third, a marked dissimilarity in the genetic diversity between the two groups may also have resulted from several factors that caused a difference in the effective population sizes.</P>
Lu, Feng,Lim, Chae Seung,Nam, Deok Hwa,Kim, Kwonkee,Lin, Khin,Kim, Tong-Soo,Lee, Hyeong-Woo,Chen, Jun-Hu,Wang, Yue,Sattabongkot, Jetsumon,Han, Eun-Taek Allen Press, etc.] 2010 The American journal of tropical medicine and hygi Vol.83 No.3
<P>Parasite dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) are known target enzymes of antifolate drugs used for the treatment and prophylaxis of persons with malaria. We sequenced the Plasmodium vivax dihydrofolate reductase (pvdhfr) and dihydropteroate synthase (pvdhps) genes to examine the prevalence and extent of point mutations in isolates from malaria-endemic countries. Double mutations (S58R and S117N) or quadruple mutations (F57L/I, S58R, T61M, and S117T) in the pvdhfr gene were found in isolates from Thailand (96.4%) and Myanmar (71.4%), but in only one isolate (1.0%) from Korea, where sulfadoxine-pyrimethamine has never been used. The pvdhfr point mutations correlated strongly with the pvdhps point mutations and ranged from single to triple mutations (S382A, A383G, and A553G), among isolates from Thailand, Myanmar, and Korea. These findings suggests that the prevalence of mutations in pvdhfr and pvdhps in P. vivax isolates from different malaria-endemic countries is associated with selection pressure imposed by sulfadoxine-pyrimethamine.</P>
Burden of dengue infection and disease in a pediatric cohort in urban Sri Lanka.
Tissera, Hasitha,Amarasinghe, Ananda,De Silva, Aruna Dharshan,Kariyawasam, Pradeep,Corbett, Kizzmekia S,Katzelnick, Leah,Tam, Clarence,Letson, G William,Margolis, Harold S,de Silva, Aravinda M Allen Press, etc.] 2014 The American journal of tropical medicine and hygi Vol.91 No.1
<P>Dengue is the most significant arthropod-borne viral infection of humans. Persons infected with dengue viruses (DENV) have subclinical or clinically apparent infections ranging from undifferentiated fever to dengue hemorrhagic fever/shock syndrome. Although recent studies estimated that the Indian subcontinent has the greatest burden of DENV infection and disease worldwide, we do not have reliable, population-based estimates of the incidence of infection and disease in this region. The goal of this study was to follow-up a cohort of 800 children living in a heavily urbanized area of Colombo, Sri Lanka to obtain accurate estimates of the incidence of DENV infection and disease. Annual blood samples were obtained from all children to estimate dengue seroprevalence at enrollment and to identify children exposed to new DENV infections during the study year. Blood was also obtained from any child in whom fever developed over the course of the study year to identify clinically apparent DENV infections. At enrollment, dengue seroprevalence was 53.07%, which indicated high transmission in this population. Over the study year, the incidence of DENV infection and disease were 8.39 (95% confidence interval = 6.56-10.53) and 3.38 (95% confidence interval = 2.24-4.88), respectively, per 100 children per year. The ratio of clinically inapparent to apparent infections was 1.48. These results will be useful for obtaining more accurate estimates of the burden of dengue in the region and for making decisions about testing and introduction of vaccines.</P>
Relative Bradycardia in Scrub Typhus
Jung, Lae Young,Jeon, Mir,Choi, Seung Hee,Hwang, Joo-Hee,Lee, Chang-Seop,Rhee, Kyoung-Suk Allen Press, etc 2017 The American journal of tropical medicine and hygi Vol.97 No.5
<P>To investigate the relationship between heart rate and temperature, we examined 493 febrile patients with documented disease. These patients were diagnosed serologically and analyzed retrospectively: 337 (68.4%) responded to fever with increased heart rate < 10 beats/minute/degrees C (relative bradycardia [RB]), and 156 patients had a heart rate response >= 10 beats/minute/degrees C (general heart rate increase [GHRI]). The RB group had a higher median resting heart rate and lower heart rate at maximum temperature than the GHRI group. Despite differences in heart rate response, no significant differences were seen in clinical outcomes (acute kidney injury, systemic inflammatory response syndrome (SIRS), and death). We concluded that most patients with scrub typhus presented with RB. In scrub typhus infection, RB can be included as one of the clinical features for differential diagnosis from other infectious diseases.</P>