http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : rz, A. S. (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
Ustekinumab pharmacokinetics after subcutaneous administration in swine model
Tomasz Grabowski,Artur Burmańczuk,Rafał Derlacz,Tadeusz Stefaniak,Anna Rząsa,Jacek Borkowski 대한수의학회 2021 Journal of Veterinary Science Vol.22 No.5
Background: Due to multiple similarities in the structure and physiology of human and pig skin, the pig model is extremely useful for biological drug testing after subcutaneous administration. Knowledge of the differences between subcutaneous injection sites could have a significant impact on the absorption phase and pharmacokinetic profiles of biological drugs. Objectives: This study aimed to analyze the impact of administration site on pharmacokinetics and selected biochemical and hematological parameters after a single subcutaneous administration of ustekinumab in pigs. Drug concentrations in blood plasma were analyzed by enzyme-linked immunosorbent assay. Pharmacokinetic analyses were performed based on raw data using Phoenix WinNonlin 8.1 software and ThothPro v 4.1. Methods: The study included 12 healthy, female, large white piglets. Each group received a single dose of ustekinumab given as a 1 mg/kg subcutaneous injection into the internal part of the inguinal fold or the external part of the inguinal fold. Results: The differences in absorption rate between the internal and external parts of the inguinal fold were not significant. However, the time of maximal concentration, clearance, area under the curve calculated between zero and mean residence time and mean residence time between groups were substantially different (p > 0.05). The relative bioavailability after administration of ustekinumab into the external part of the inguinal fold was 40.36% lower than after administration of ustekinumab into the internal part of the inguinal fold. Conclusions: Healthy breeding pigs are a relevant model to study the pharmacokinetic profile of subcutaneously administered ustekinumab.
-
Esra Sinem Kemer Doğan,Burak Doğan,Özlem Fentoğlu,Fatma Yeşim Kırzıoğlu 대한치주과학회 2019 Journal of Periodontal & Implant Science Vol.49 No.2
Purpose: An unresolved inflammatory state contributes to the pathogenesis of periodontal disease and metabolic syndrome (MetS). Therefore, the purpose of this study was to evaluate the role of lipoxin A4 (LXA4), a proresolving lipid mediator, in the association between periodontal disease and MetS. Methods: Sixty-seven patients with MetS and 65 patients without MetS were included in the study. Sociodemographic information was obtained via a questionnaire, and detailed medical diagnoses were made. Periodontal parameters (plaque index [PI], gingival index [GI], probing pocket depth [PD], and clinical attachment level [CAL]) and metabolic parameters were measured, and serum LXA4 levels were determined. The associations among MetS, periodontal parameters, and serum LX levels were evaluated by adjusted multivariate linear regression analyses. Results: Patients with MetS were older and had a higher body mass index than patients without MetS. Periodontal parameters (PI, GI, PD, and CAL) were higher in patients with MetS than in those without MetS. Serum LXA4 levels were higher in patients without MetS. Multivariate linear regression analysis indicated a positive association between MetS and periodontal parameters (PD and CAL). Negative associations were established between MetS and LXA4 levels, and between LXA4 and periodontal parameters (PI, PD, and CAL). Conclusions: The presence of higher values of periodontal parameters in patients with MetS and the negative relationship of LXA4 with MetS and periodontal disease may support the protective role of proresolving lipid mediators in the association between periodontal disease and MetS.
-
Özlem Fentoğlu,Memduha Tözüm Bulut,Burak Doğan,Fatma Yeşim Kırzıoğlu,Esra Sinem Kemer Doğan 대한치주과학회 2020 Journal of Periodontal & Implant Science Vol.50 No.3
Purpose: The aim of this study was to evaluate the serum levels of oxidized low-density lipoprotein (oxLDL), anti-oxLDL, and myeloperoxidase (MPO) in hyperlipidemic patients with periodontal disease. Methods: This study included 123 patients with hyperlipidemia categorized based on metabolic control as mild to moderate (H1) (n=66) or poor (H2) (n=57), as well as systemically healthy controls (C) (n=68). Serum levels of lipids, oxLDL, anti-oxLDL, and MPO were evaluated, along with clinical periodontal parameters. Results: The percentage of bleeding on probing (BOP%) and the clinical attachment level were significantly higher in the H2 group than in the C group. Patients with hyperlipidemia had a relatively high risk of developing periodontal disease. The oxLDL and anti-oxLDL levels were higher in H2 patients with periodontitis than in the control or H1 patients with periodontitis. In the H1 and H2 groups, the ratio of total cholesterol to high-density lipoprotein was significantly correlated with gingival index, BOP%, and oxLDL levels. Conclusions: Our findings indicate that the lipoprotein-associated inflammatory mediators of oxLDL, anti-oxLDL, and MPO may play an important role in the relationship between periodontal disease and hyperlipidemia.
-
Tang, X.,Schneider, J.,Dollinger, A.,Luo, Y.,Wö,rz, A. S.,Judai, K.,Abbet, S.,Kim, Y. D.,Gantefö,r, G. F.,Fairbrother, D. H.,Heiz, U.,Bowen, K. H.,Proch, S. The Royal Society of Chemistry 2014 Physical chemistry chemical physics Vol.16 No.14
<P>Recent research in heterogeneous catalysis, especially on size-selected model systems under UHV conditions and also in realistic catalytic environments, has proved that it is necessary to think in terms of the exact number of atoms when it comes to catalyst design. This is of utmost importance if the amount of noble metal, gold in particular, is to be reduced for practical reactions like CO oxidation. Here it is shown that on TiO<SUB>2</SUB> only Au<SUB>6</SUB> and Au<SUB>7</SUB> clusters are active for CO oxidation which holds for the single crystal, thin films, and titania clusters deposited on HOPG. Size-selected cluster deposition and TPD methods have been employed to investigate the CO oxidation activity of Au<SUB><I>n</I></SUB>/TiO<SUB>2</SUB> systems which are compared to recent results reported by Lee <I>et al.</I> to form a consistent picture in which only two species can be regarded as “active”. The efficiency of investigated Au<SUB><I>n</I></SUB>/(TiO<SUB>2</SUB>)<SUB>93</SUB>/HOPG composite materials is attributed to carbon-assisted oxygen spillover from gold to support particles and across grain boundaries.</P> <P>Graphic Abstract</P><P>The probability of creating CO oxidation-active species on TiO<SUB>2</SUB> is very small since only Au<SUB>6</SUB> and Au<SUB>7</SUB> are catalytically active. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4cp00160e'> </P>
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
