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Huebsch, Nathaniel,Kearney, Cathal J.,Zhao, Xuanhe,Kim, Jaeyun,Cezar, Christine A.,Suo, Zhigang,Mooney, David J. National Academy of Sciences 2014 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.111 No.27
<P>Biological systems are exquisitely sensitive to the location and timing of physiologic cues and drugs. This spatiotemporal sensitivity presents opportunities for developing new therapeutic approaches. Polymer-based delivery systems are used extensively for attaining localized, sustained release of bioactive molecules. However, these devices typically are designed to achieve a constant rate of release. We hypothesized that it would be possible to create digital drug release, which could be accelerated and then switched back off, on demand, by applying ultrasound to disrupt ionically cross-linked hydrogels. We demonstrated that ultrasound does not permanently damage these materials but enables nearly digital release of small molecules, proteins, and condensed oligonucleotides. Parallel in vitro studies demonstrated that the concept of applying temporally short, high-dose “bursts” of drug exposure could be applied to enhance the toxicity of mitoxantrone toward breast cancer cells. We thus used the hydrogel system in vivo to treat xenograft tumors with mitoxantrone, and found that daily ultrasound-stimulated drug release substantially reduced tumor growth compared with sustained drug release alone. This approach of digital drug release likely will be applicable to a broad variety of polymers and bioactive molecules, and is a potentially useful tool for studying how the timing of factor delivery controls cell fate in vivo<I>.</I></P>
Inorganic islands on a highly stretchable polyimide substrate
Sun, Jeong-Yun,Lu, Nanshu,Yoon, Juil,Oh, Kyu-Hwan,Suo, Zhigang,Vlassak, Joost J. Cambridge University Press (Materials Research Soc 2009 Journal of materials research Vol.24 No.11
<P>For a flexible electronic device integrating inorganic materials on a polymer substrate, the polymer can deform substantially, but the inorganic materials usually fracture at small strains. This paper describes an approach to make such a device highly stretchable. A polyimide substrate is first coated with a thin layer of an elastomer, on top of which SiN<I>x</I> islands are fabricated. When the substrate is stretched to a large strain, the SiN<I>x</I> islands remain intact. Calculations confirm that the elastomer reduces the strain in the SiN<I>x</I> islands by orders of magnitude.</P>
유연전자회로를 위한 폴리머 기판/세라믹 아일랜드를 사용한 획기적 유연성 확보기술
윤주일(Juil Yoon),선정윤(Jeong-Yun Sun),오규환(Kyu-Hwan Oh),Joost J.Vlaask,Zhigang Suo 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.11
For a flexible electronic device integrating inorganic materials on a polymer substrate, the polymer can deform substantially, but the inorganic materials usually fracture at small strains. In this work, we show a novel approach to make such a device highly stretchable. A polyimide substrate is first coated with a thin layer of an elastomer, on top of which SiNx islands are fabricated. When the substrate is stretched to a large strain, the SiNx islands remain intact. Our simple model illustrates that the very small stiffness of the interlayer is the key to significantly reduce strains in the islands and therefore the stretchability of polymersupported ceramic island arrays has been improved remarkably.