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- 저자 : Zhi-Juan Liao (검색결과 3 건)
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Energy efficiency characteristic analysis of tri‑coil PT symmetric MC‑WPT systems
Zhi-Juan Liao,Qi-Wei Zhu,Wen Ren,Chen-Yang Xia,Xu Liu 전력전자학회 2023 JOURNAL OF POWER ELECTRONICS Vol.23 No.9
The parity-time (PT) symmetric magnetic coupling wireless power transfer (MC-WPT) system has received a great deal of attention since it was proposed. Its transmission efficiency has been greatly improved when compared with previous research. The operational amplifier (OA) is a typical construction method for PT symmetric MC-WPT systems. On this basis, to achieve a higher transmission efficiency and a longer effective power transmission distance at the same time, this paper constructs an OA-based tri-coil PT symmetric MC-WPT system. The analytical expressions of its singularity, PT symmetric state, and PT symmetric broken state are obtained. Then a complete set of parameter design criteria for the tri-coil PT symmetric system is derived. The transmission efficiency and resonant frequency of two-coil and tri-coil system are simulated on MATLAB software, and the simulation results are consistent with the theoretical analysis results. Finally, an experimental device is constructed to further verify the correctness of the theory. This paper demonstrates that the effective power transmission distance of the tri-coil PT symmetric MC-WPT system is more than twice that of the two-coil PT symmetric MC-WPT system, which can achieve a good balance between transmission efficiency and transmission distance.
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Ying-ying Xu,Hai-ru Yu,Jia-yi Sun,Zhao Zhao,Shuang Li,Xin-feng Zhang,Zhi-xuan Liao,Ming-ke Cui,Juan Li,Chan Li,Qiang Zhang 대한암학회 2019 Cancer Research and Treatment Vol.51 No.2
Purpose Although the interferon (IFN) signaling and the paired-like homeodomain transcription factor 2 (PITX2) have both been implicated in the progression of breast cancer (BCa), it remains obscure whether these two pathways act in a coordinated manner. We therefore aimed to elucidate the expression and function of PITX2 during the pathogenesis of endocrine resistance in BCa. Materials and Methods PITX2 expression was assessed in BCa tissues using quantitative reverse transcription polymerase chain reaction (RT-qPCR) and immunohistochemistry and in experimentally induced letrozole-resistant BCa cells using RT-qPCR and immunoblotting. Effects of PITX2 deregulation on BCa progression was determined by assessing MTT, apoptosis and xenograft model. Finally, using multiple assays, the transcriptional regulation of interferon-inducible transmembrane protein 1 (IFITM1) by PITX2 was studied at both molecular and functional levels. Results PITX2 expression was induced in letrozole-resistant BCa tissues and cells, and PITX2 induction by IFN signaling powerfully protected BCa cells against letrozole insult and potentiated letrozole-resistance. Mechanistically, PITX2 enhanced IFN-induced AKT activation by transactivating the transcription of IFITM1, thus rendering BCa cells unresponsive to letrozoleelicited cell death. Additionally, ablation of IFITM1 expression using siRNA substantially abolished IFN-elicited AKT phosphorylation, even in the presence of PITX2 overexpression, thus sensitizing BCa cells to letrozole treatment. Conclusion These results demonstrate that constitutive upregulation of PITX2/IFITM1 cascade is an intrinsic adaptive mechanism during the pathogenesis of letrozole-resistance, and modulation of PITX2/IFITM1 level using different genetic and pharmacological means would thus have a novel therapeutic potential against letrozole resistance in BCa.
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Expression and Functional Role of ALDH1 in Cervical Carcinoma Cells
Rao, Qun-Xian,Yao, Ting-Ting,Zhang, Bing-Zhong,Lin, Rong-Chun,Chen, Zhi-Liao,Zhou, Hui,Wang, Li-Juan,Lu, Huai-Wu,Chen, Qin,Di, Na,Lin, Zhong-Qiu Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4
Tumor formation and growth is dictated by a very small number of tumor cells, called cancer stem cells, which are capable of self-renewal. The genesis of cancer stem cells and their resistance to conventional chemotherapy and radiotherapy via mechanisms such as multidrug resistance, quiescence, enhanced DNA repair abilities and anti-apoptotic mechanisms, make it imperative to develop methods to identify and use these cells as diagnostic or therapeutic targets. Aldehyde dehydrogenase 1 (ALDH1) is used as a cancer stem cell marker. In this study, we evaluated ALDH1 expression in CaSki, HeLa and SiHa cervical cancer cells using the Aldefluor method to isolate ALDH1-positive cells. We showed that higher ALDH1 expression correlated with significantly higher rates of cell proliferation, microsphere formation and migration. We also could demonstrate that SiHa-ALDH1-positive cells were significantly more tumorigenic compared to SiHa-ALDH1-negative cells. Similarly, SiHa cells overexpressing ALDH1 were significantly more tumorigenic and showed higher rates of cell proliferation and migration compared to SiHa cells where ALDH1 expression was knocked down using a lentivirus vector. Our data suggested that ALDH1 is a marker of cervical cancer stem cells and expand our understanding of its functional role.
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