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      • Construction of a Protein-Protein Interaction Network for Chronic Myelocytic Leukemia and Pathway Prediction of Molecular Complexes

        Zhou, Chao,Teng, Wen-Jing,Yang, Jing,Hu, Zhen-Bo,Wang, Cong-Cong,Qin, Bao-Ning,Lv, Qing-Liang,Liu, Ze-Wang,Sun, Chang-Gang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13

        Background: Chronic myelocytic leukemia is a disease that threatens both adults and children. Great progress has been achieved in treatment but protein-protein interaction networks underlining chronic myelocytic leukemia are less known. Objective: To develop a protein-protein interaction network for chronic myelocytic leukemia based on gene expression and to predict biological pathways underlying molecular complexes in the network. Materials and Methods: Genes involved in chronic myelocytic leukemia were selected from OMIM database. Literature mining was performed by Agilent Literature Search plugin and a protein-protein interaction network of chronic myelocytic leukemia was established by Cytoscape. The molecular complexes in the network were detected by Clusterviz plugin and pathway enrichment of molecular complexes were performed by DAVID online. Results and Discussion: There are seventy-nine chronic myelocytic leukemia genes in the Mendelian Inheritance In Man Database. The protein-protein interaction network of chronic myelocytic leukemia contained 638 nodes, 1830 edges and perhaps 5 molecular complexes. Among them, complex 1 is involved in pathways that are related to cytokine secretion, cytokine-receptor binding, cytokine receptor signaling, while complex 3 is related to biological behavior of tumors which can provide the bioinformatic foundation for further understanding the mechanisms of chronic myelocytic leukemia.

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        Analysis of dynamic behavior for truss cable structures

        Wen-Fu Zhang,Ying-Chun Liu,Jing Ji,Zhen-Chao Teng 국제구조공학회 2014 Steel and Composite Structures, An International J Vol.16 No.2

        Natural vibration of truss cable structures is analyzed based upon the general structural analysis software ANSYS, energy variational method and Rayleigh method, the calculated results of three methods are compared, from which the characteristics of free-vibration are obtained. Moreover, vertical seismic response analysis of truss cable structures is carried out via time-history method. Introducing three natural earthquake waves calculated the results including time-history curve of vertical maximal displacement, time-history curve of maximal internal force. Variation curve of maximal displacement of node along span, and variation curve of maximal internal force of member along span are presented. The results show the formulas of frequencies for truss cable structures obtained by energy variational method are of high accuracy. Furthermore, the maximal displacement and the maximal internal force occur near the 1/5 span point. These provide convenient and simple design method for practical engineering.

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