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- 저자 : Zhaocai Zhang (검색결과 2 건)
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Yu Zhu,Zhaocai Zhang 한국고분자학회 2014 Macromolecular Research Vol.22 No.12
In this work, hollow fiber membrane was prepared from poly(vinylidene fluoride) (PVDF)/triethyl phosphate(TEP)/water systems by modified non-solvent induced phase separation technique (mNIPS), which was characterizedin the process with relative high polymer content of 30 wt% in spinning dope. The ternary phase diagramand precipitation rate were determined to elucidate the various membrane formation mechanisms, and the membranesmorphologies were observed by field emission scanning electronic microscopy (FESEM). It was indicatedthat the phase separation mechanism was found to heavily depend on the bath strength. Although the solid-liquiddemixing process initiated the precipitation process, by changing the bath gradually from pure water to 40% TEP,the liquid-liquid demixing occurred earlier and earlier. Accordingly the top surface morphologies evolved from adense skin (asymmetric membrane) to a totally porous morphology (symmetric membrane). In addition, the permeability,maximum stress at break, medium pore size and porosity of hollow fiber membranes were also investigated. In conclusion, the successful application of modified non-solvent induced phase separation (mNIPS) may providean effective route to improve the membrane structure modulation.
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Yanqi Li,Jun Qin,Zhaocai He,Guang Cui,Kun Zhang,Buqiang Wu 한국유전학회 2021 Genes & Genomics Vol.43 No.2
Background Circular RNAs (circRNAs) are a crucial class of regulatory RNAs in cancer procession, including papillary thyroid cancer (PTC). Circ-Pumilio 1 (circPUM1) is a novel circRNA with the oncogenic function in ovarian cancer and lung cancer. However, the role of circPUM1 in PTC is undiscovered. Objective This study was performed to investigate the biological function and molecular mechanism of circPUM1 in PTC. Methods CircPUM1 and microRNA-21-5p (miR-21-5p) levels were analyzed via quantitative real-time polymerase chain reaction (qRT-PCR). Cellular viability and metastasis were measured using Cell Counting Kit 8 (CCK-8) and transwell migration/invasion assay. Glycolysis was evaluated by glucose uptake and lactate production. Associated proteins were examined applying with western blot. Dual-luciferase reporter assay and RNA pull-down assay were used to analyze the interaction between circPUM1 or mitogen-activated protein kinase 1 (MAPK1) and miR-21-5p. Moreover, the role of circPUM1 in vivo was explored by xenograft tumor experiment. Results Signifcantly, circPUM1 was upregulated in PTC tissue samples and cells. Cell growth, metastasis and glycolytic process of PTC cells were all inhibited after downregulation of circPUM1. Besides, circPUM1 could sponge miR-21-5p and MAPK1 was a target gene of miR-21-5p. Furthermore, we found that the anti-cancer efect of circPUM1 knockdown on PTC was partly ascribed to MAPK1 downregulation by upregulating miR-21-5p. Silencing circPUM1 also impeded tumorigenesis of PTC in vivo via miR-21-5p/MAPK1 axis. Conclusion These fndings suggested that circPUM1 knockdown inhibited MAPK1 expression by targeting miR-21-5p, consequently leading to the repressive efect on PTC progression. CircPUM1 might be a promising target to improve the diagnosis and treatment of PTC.
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