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        Effects and Predictive Factors of Immunosuppressive Therapy Combined with Umbilical Cord Blood Infusion in Patients with Severe Aplastic Anemia

        Xia Zhang,Zhangzhi Li,Wei Geng,Bin Song,Chucheng Wan 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.5

        Purpose: To investigate the efficacy and safety of umbilical cord blood (UCB) infusion (UCBI) plus immunosuppressive therapy (IST)treatment in comparison to IST treatment, as well as predictive factors for clinical responses, in severe aplastic anemia (SAA) patients. Materials and Methods: Totally, 93 patients with SAA were enrolled in this cohort study. In the IST group, rabbit antithymocyte globulin(r-ATG) combined with cyclosporine A (CsA) was administered, while in the IST+UBCI group, r-ATG, CsA, and UCB were used. Results: After 6 months of treatment, UCBI+IST achieved a higher complete response (CR) rate (p=0.002) and an elevated overallresponse rate (ORR) (p=0.004), compared to IST. Regarding hematopoietic recovery at month 6, platelet responses in theUCBI+IST group were better than those in the IST group (p=0.002), and UCBI+IST treatment facilitated increasing trends in absoluteneutrophil count (ANC) response (p=0.056). Kaplan-Meier curves illuminated UCBI+IST achieved faster ANC response(p<0.001) and platelet response (p<0.001), compared with IST therapy. There was no difference in overall survival (OS) betweenthe two groups (p=0.620). Furthermore, logistic regression analysis demonstrated that UCBI+IST was an independent predictingfactor for both CR (p=0.001) and ORR (p<0.001), compared to IST; meanwhile, very severe aplastic anemia (VSAA) and ANC couldpredict clinical responses as well. However, Cox proportional hazard regression indicated that VSAA (p=0.003), but not UCBI+IST,affected OS. Safety profiles showed that UCBI+IST therapy did not elevate adverse events, compared with IST treatment. Conclusion: UCBI+IST achieved better clinical responses and hematopoietic recovery than IST, and was well tolerated in SAApatients.

      • Research on the Current Status of College Students of South Korea in Practising Chinese kung fu Lessons

        ( Zhang Zhi ),( Zhou Ying Li ) 한국체육학회 2015 국제스포츠과학 학술대회 Vol.2015 No.1

        Purpose: To understand and master current situation about college students of South Korea in learning Chinese martial arts courses, as well as real problem and environment about Chinese martial arts courses launched in universities of South Korea, to raise corresponding counter measures and suggestions on development of kung fu lessons in universities of South Korea, to promote the development of Kung Fu sports in universities of South Korea , to serve Internationalization of the Chinese Kung Fu sports. Method: This paper was based on a questionnaire survey which was made in Yongin Univerisity.119 questionnaires were distributed and all of them were taken back, and lastly effective rate is 100%. The survey was for getting familiar with current situation about how college students of South Korean are learning Chinese martial arts. Deep interview was made to know better about teaching and training situation of specific Chinese martial arts between teachers and students. Besides, through learning Chinese martial arts, we’d love to figure out some questions. For example: whether college students of South Korea can deepen the understanding of China, Chinese culture and Chinese martial arts or not? Whether they are more willing to learn Chinese culture and Chinese martial arts, as well as how do colleges and universities of South Korean promote Chinese martial arts in a more efficient way? Result: Few universities in South Korea are currently establishing Chinese martial arts courses, The development of sports of South Korea have private characteristics and their own way , so being foreign sports project in South Korea, promoting can be certain difficult, but the trend is very good; students are satisfied with teacher``s attitude and approach of teaching in the learning process, and also are able to understand the Chinese culture through learning martial arts, but what students learned about Chinese culture is vague, which are not clear and concrete, not to mention identity of Chinese culture, which are related with the forms of promotion of martial arts and means; While comparing with some specific sports like South Korea Taekwondo, Chinese martial arts is a lack of skill and difficult to learn the complex movement; but for most of the students, they are willing to keep on learning Chinese martial arts if there are any opportunity in the future. Conclusion: As Chinese martial arts became a formal event in some international competitions like the Asian Games and World University Games, as well as program of the Olympic Games martial arts of China, more and more countries have gradually realized the importance of China martial arts project, so it’s an inevitable trend that Chinese martial arts are established in universities of South Korea; The contents of teaching should be adaptive to the psychology and demand of college students of South Korea when Chinese martial arts are taught in universities of South Korea. Here are some examples: the martial arts project should be more simple, interesting and practical, and also a variety of teaching methods should be adopt in the process of teaching, such as the combination of theory and practice, the combination of music and video, and collective creation and performance of teaching content. This improvement will enhance the learning enthusiasm of stu- dents and achieve better teaching effect. In addition; it’s also another way of promoting Chinese culture when Chinese martial arts are more widely established in universities of South Korea, So Chinese culture should be deeply expressed in the dissemination contents of Chinese martial arts, methods of teaching and process of teaching and practicing. The nature of China martial arts should be raised as culture of arts, and eventually college students of South Korea will deeply grasp new Chinese ideas of culture.

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