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Research on the Development of E-commerce for Poverty Alleviation in Wumeng Mountain Area of Yunnan
Hong Runzhang,Huang Congyan,Zhang Lanlan,Gao Xinglin 아시아사회과학학회 2020 Jornal of Asia Social Science Vol.1 No.3
Under the background of poverty alleviation, aiming at realizing the scientific, large-scale and intelligent development of Wumeng Mountain’s industry and the overall revitalization of the countryside, it is important to consider how to make good use of e-commerce tools in Wumeng Mountain, Yunnan, fully understand the importance of e-commerce poverty alleviation, combine the characteristics and advantages of regional industrial development, effectively resolve the constraints in the process of e-commerce poverty alleviation, optimize the combination of different e-commerce poverty alleviation models, innovate the development mechanism, and scientifically implement e-commerce poverty alleviation.
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Guo Caiyun,Liu Zhiqiang,Zhang Congyan 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.3
The rapid development of E-commerce has prompted increasing demand for express services. Improving service quality from the customers perception has become an important way for the private express enterprises to face the fierce market competition. This paper summarizes the customers perception service quality theory and the express enterprises’ service quality evaluation methods, and establishes an index system of private express enterprises’ service quality evaluation from the perspective of the customers perception. The SPSS software is used to detect the feasibility of the established evaluation index system. The information entropy theory is applied to calculate the index weight value, and the evaluation model of private express enterprises’ service quality is established by combining the entropy weight with the unascertained measure method. Finally, this paper carries out the empirical analysis based on the JY express enterprise’s service quality,and puts forward the relevant countermeasures and suggestions. The purpose of the paper is to provide a new scientific method for the service quality evaluation of the private express enterprises.
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Jiachen Shi,Qiuling Ma,Wenting Su,Congyan Liu,Huangqin Zhang,Yuping Liu,Xiaoqi Li,Xi Jiang,Chang Ge,Fei Kong,Yan Chen,Ding Qu 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Conventional dissolving microneedles (DMNs) face significant challenges in anti-melanoma therapy due to the lack of active thrust to achieve efficient transdermal drug delivery and intra-tumoral penetration. Methods In this study, the effervescent cannabidiol solid dispersion-doped dissolving microneedles (Ef/CBD-SD@ DMNs) composed of the combined effervescent components (CaCO3 & NaHCO3) and CBD-based solid dispersion (CBD-SD) were facilely fabricated by the “one-step micro-molding” method for boosted transdermal and tumoral delivery of cannabidiol (CBD). Results Upon pressing into the skin, Ef/CBD-SD@DMNs rapidly produce CO2 bubbles through proton elimination, significantly enhancing the skin permeation and tumoral penetration of CBD. Once reaching the tumors, Ef/CBD-SD@ DMNs can activate transient receptor potential vanilloid 1 (TRPV1) to increase Ca2+ influx and inhibit the downstream NFATc1-ATF3 signal to induce cell apoptosis. Additionally, Ef/CBD-SD@DMNs raise intra-tumoral pH environment to trigger the engineering of the tumor microenvironment (TME), including the M1 polarization of tumor-associated macrophages (TAMs) and increase of T cells infiltration. The introduction of Ca2+ can not only amplify the effervescent effect but also provide sufficient Ca2+ with CBD to potentiate the anti-melanoma efficacy. Such a “one stone, two birds” strategy combines the advantages of effervescent effects on transdermal delivery and TME regulation, creating favorable therapeutic conditions for CBD to obtain stronger inhibition of melanoma growth in vitro and in vivo. Conclusions This study holds promising potential in the transdermal delivery of CBD for melanoma therapy and offers a facile tool for transdermal therapies of skin tumors.
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