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      • BACH: Grand challenge on breast cancer histology images

        Aresta, Guilherme,Araú,jo, Teresa,Kwok, Scotty,Chennamsetty, Sai Saketh,Safwan, Mohammed,Alex, Varghese,Marami, Bahram,Prastawa, Marcel,Chan, Monica,Donovan, Michael,Fernandez, Gerardo,Zeineh, J Elsevier 2019 Medical image analysis Vol.56 No.-

        <P><B>Abstract</B></P> <P>Breast cancer is the most common invasive cancer in women, affecting more than 10% of women worldwide. Microscopic analysis of a biopsy remains one of the most important methods to diagnose the type of breast cancer. This requires specialized analysis by pathologists, in a task that i) is highly time- and cost-consuming and ii) often leads to nonconsensual results. The relevance and potential of automatic classification algorithms using hematoxylin-eosin stained histopathological images has already been demonstrated, but the reported results are still sub-optimal for clinical use. With the goal of advancing the state-of-the-art in automatic classification, the Grand Challenge on BreAst Cancer Histology images (BACH) was organized in conjunction with the 15th International Conference on Image Analysis and Recognition (ICIAR 2018). BACH aimed at the classification and localization of clinically relevant histopathological classes in microscopy and whole-slide images from a large annotated dataset, specifically compiled and made publicly available for the challenge. Following a positive response from the scientific community, a total of 64 submissions, out of 677 registrations, effectively entered the competition. The submitted algorithms improved the state-of-the-art in automatic classification of breast cancer with microscopy images to an accuracy of 87%. Convolutional neuronal networks were the most successful methodology in the BACH challenge. Detailed analysis of the collective results allowed the identification of remaining challenges in the field and recommendations for future developments. The BACH dataset remains publicly available as to promote further improvements to the field of automatic classification in digital pathology.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The BACH challenge was organized to push forward methods for automatic classification of breast cancer biopsies using clinical hematoxylin-eosin stained histopathological images. </LI> <LI> A large public dataset, composed of 400 microscopy images and 30 whole-slide images, was specifically compiled for the BACH challenge. </LI> <LI> A total of 64 methods were submitted, out of 677 registration, and a detailed comparative analysis was carried out for the methods with higher accuracy scores. </LI> <LI> Several submitted algorithms performed better than the state-of-the-art in terms of accuracy (top score of 87%). </LI> <LI> Convolutional neural networks dominated the submissions, and was the method of choice in the algorithm that won the challenge. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

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