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- 저자 : Yuwei Lan (검색결과 2 건)
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Fuwang Moa,Liya Zhou,Qi Pang,Yuwei Lan,Zhijuan Liang,유재수 한국물리학회 2013 Current Applied Physics Vol.13 No.2
Zn1exNb2O6:Eu3+ x , Zn0.95-yNb2O6:Eu3+ 0:05, Bi3+ y , and Zn0.890Nb2O6:Eu3+ 0:05, Bi3þ 0:005, M+ 0:055 (M ¼ Li, Na, K) redemitting phosphors were synthesized via solegel method. X-ray power diffraction, scanning electron microscopy, photoluminescence excitation, and emission spectra (PL) were used to characterize the phosphors. The obtained Zn1-xNb2O6:Eu3+ x phosphor showed a stronger excitation band near 400 nm. When Eu3+ and Bi3+ were incorporated into the ZnNb2O6 lattice, a broad band from 300 nm to 350 nm with the center at 329 nm appeared. Taking the ion size difference of Liþ (59 pm), Naþ (99 pm), Kv (137 pm), Eu3+ (95 pm), and Zn2+ (60 pm), the emitting intensity of the phosphor increased observably by adding Liþ and Naþ as charge compensators. The PL intensity of the Kþ-doped in Zn0.945Nb2O6:Eu3+ 0:05, Bi3+ 0:005 was slightly less than those of Zn0.945Nb2O6:Eu3þ 0:05, Bi3 þ 0:005. The chromaticity coordinates of Zn0.890Nb2O6:Eu3+ 0:05, Bi3+ 0:005, Li+ 0:055 (x ¼ 0.67, y ¼ 0.34) were close to the standard of National Television Standard Committee values (x ¼ 0.670, y ¼ 0.330). The fabricated light-emitting diode (LED) further confirmed that the Zn0.890Nb2O6:Eu3+ 0:05, Bi3+ 0:005, Liþ 0:055 phosphors can efficiently absorb up to 400 nm irradiation and emit red light, and are potential candidates as red-emitting components for white LED.
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Han, Qianqian,Yang, Pishan,Wu, Yuwei,Meng, Shu,Sui, Lei,Zhang, Lan,Yu, Liming,Tang, Yin,Jiang, Hua,Xuan, Dongying,Kaplan, David L.,Kim, Sung Hoon,Tu, Qisheng,Chen, Jake Mary Ann Liebert 2015 Tissue engineering. Part A Vol.21 No.15
<P>Epigenetic regulation of gene expression is a central mechanism that governs cell stemness, determination, commitment, and differentiation. It has been recently found that PHF8, a major H4K20/H3K9 demethylase, plays a critical role in craniofacial and bone development. In this study, we hypothesize that PHF8 promotes osteoblastogenesis by epigenetically regulating the expression of a nuclear matrix protein, special AT-rich sequence-binding protein 2 (SATB2) that plays pivotal roles in skeletal patterning and osteoblast differentiation. Our results showed that expression levels of PHF8 and SATB2 in preosteoblasts and bone marrow stromal cells (BMSCs) increased simultaneously during osteogenic induction. Overexpressing PHF8 in these cells upregulated the expression of SATB2, Runx2, osterix, and bone matrix proteins. Conversely, knockdown of PHF8 reduced the expression of these genes. Furthermore, ChIP assays confirmed that PHF8 specifically bound to the transcription start site (TSS) of the SATB2 promoter, and the expression of H3K9me1 at the TSS region of SATB2 decreased in PHF8 overexpressed group. Implantation of the BMSCs overexpressing PHF8 with silk protein scaffolds promoted bone regeneration in critical-sized defects in mouse calvaria. Taken together, our results demonstrated that PHF8 epigenetically modulates SATB2 activity, triggering BMSCs osteogenic differentiation and facilitating bone formation and regeneration in biodegradable silk scaffolds.</P>
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