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- 저자 : Yunna Wang (검색결과 3 건)
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Yanmei Liu,Yunna Sun,Yan Wang,Guifu Ding,Bin Sun,Xiaolin Zhao 대한금속·재료학회 2017 ELECTRONIC MATERIALS LETTERS Vol.13 No.1
A complex reinforced polymer interposer comprised with conductive Nicylinders, ordered Ni grid and SiC nano-whiskers/Polyimide (PI)composite was proposed. The conductive Ni cylinders distributing in themiddle of each Ni grid unite designed as the supporting structure wereused as electric connecting component for the interposer and wereinsulated by the SiC nano-whiskers/PI composite. The comprehensiveproperties of the complex reinforced polymer interposer were improvedby a complex reinforced mechanism: the improved thermal conductivityand mechanical strength by the Ni supporting structure and the reducedmetal/polymer interfacial mismatch due to the SiC nano-whiskers/PIcomposite with the optimized mixture ratio. The above complexreinforced polymer interposer and a traditional reinforced polymerinterposer only with Ni grid were fabricated using micro-machiningtechnology for comparative analysis. The comprehensive properties ofthese two polymer interposers were analyzed respectively. Comparedwith the traditional design, the comprehensive properties of the proposedcomplex reinforced polymer interposer were improved further, such as,21.3% increase for the Young modulus, 10.1% decrease for thecoefficient of thermal expansion (CTE) and 54.9% increase for thethermal conductivity. Such complex reinforced mechanism based on themetal ordered grid and random nano-whiskers has potential to expandthe applications of the polymer interposer.
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Comparison of SDE and SPME for the analysis of volatile compounds in butters
Yang Liu,Yunna Wang,Dongdong Yuan,Yan Li,Liebing Zhang 한국식품과학회 2020 Food Science and Biotechnology Vol.29 No.1
The current study aimed to compare the effectiveness of two extraction techniques, namely simultaneous distillation–extraction (SDE) and solid-phase microextraction (SPME), in evaluating key aroma compounds in butters. Volatile compounds’ contributions to butter flavors were evaluated employing both odor active values (OAVs) and gas chromatography olfactometry (GC-O). The results showed that the species of volatile compounds detected by the two techniques were almost the same, whereas their volatile profiles were obviously different. Using SDE method, methyl ketones took up the largest proportion of the volatile compounds, followed by fatty acids. Using SPME method, the most abundant compounds were the fatty acids, followed by lactones. More methyl ketones were detected in the SDE extract owing to lipid degradation as a consequence of the high temperature during extraction. Lactones were considered to be the key aroma compounds, especially d-decalactone, which was identified by both OAVs and GC-O.
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Zhao Nairui,Su Na,Wang Guangya,Fu Dongxia,Gao Fang,Zhang Yunna 대한독성 유전단백체 학회 2021 Molecular & cellular toxicology Vol.17 No.2
Background Pheochromocytoma (PCC) is a catecholamine-producing and neuroendocrine tumor with the 5-year overall survival of advanced stage PCC lower than 40%. Increasing evidence has shown that aberrant expression of microRNAs (miRNAs) plays important roles in the development and chemotherapy resistance of cancers including PCC. Objective The tumor-suppressive function of miR-184 has been identified in several types of cancers. The aim of this study is to explore the function and the underlying mechanism of miR-184 in the chemo-resistance of PCC. Results miR-184 expression was significantly lower in doxorubicin (Dox)-resistant pheochromocytoma-12 (PC-12) cells and PCC patients. Consistently, in vitro analysis showed that overexpression of miR-184 obviously improved the sensitivity of PC-12/Dox cells, while knockdown of miR-184 sensitised PC-12/Dox cells to chemotherapeutics. To further understand the possible functional mechanism of miR184 in the chemo-resistance of PCC, the targets of miR-184 were predicted. The results of miRDB database suggested A disintegrin and metalloproteinase 22 (ADAM22) carrying the potential complementary binding sites of miR-184 within its 3′-untranslated region (UTR). Further experiments confirmed that miR-184 bound the 3′-UTR of ADAM22 mRNA and down-regulated the expression of ADAM22 in PC-12/Dox cells. Moreover, ADAM22 was overexpressed in Dox-resistant PC-12 cells and PCC patients. Additionally, overexpression of ADAM22 attenuated miR-184-mediated chemo-sensitivity of PC-12/Dox cells. Conclusion miR-184 played a role in the chemo-sensitivity of PC-12/Dox cells at least partially via negatively regulating ADAM22. These results suggested miR-184 as a possible novel target to attenuate the chemo-resistance of PCC. Background Pheochromocytoma (PCC) is a catecholamine-producing and neuroendocrine tumor with the 5-year overall survival of advanced stage PCC lower than 40%. Increasing evidence has shown that aberrant expression of microRNAs (miRNAs) plays important roles in the development and chemotherapy resistance of cancers including PCC. Objective The tumor-suppressive function of miR-184 has been identified in several types of cancers. The aim of this study is to explore the function and the underlying mechanism of miR-184 in the chemo-resistance of PCC. Results miR-184 expression was significantly lower in doxorubicin (Dox)-resistant pheochromocytoma-12 (PC-12) cells and PCC patients. Consistently, in vitro analysis showed that overexpression of miR-184 obviously improved the sensitivity of PC-12/Dox cells, while knockdown of miR-184 sensitised PC-12/Dox cells to chemotherapeutics. To further understand the possible functional mechanism of miR184 in the chemo-resistance of PCC, the targets of miR-184 were predicted. The results of miRDB database suggested A disintegrin and metalloproteinase 22 (ADAM22) carrying the potential complementary binding sites of miR-184 within its 3′-untranslated region (UTR). Further experiments confirmed that miR-184 bound the 3′-UTR of ADAM22 mRNA and down-regulated the expression of ADAM22 in PC-12/Dox cells. Moreover, ADAM22 was overexpressed in Dox-resistant PC-12 cells and PCC patients. Additionally, overexpression of ADAM22 attenuated miR-184-mediated chemo-sensitivity of PC-12/Dox cells. Conclusion miR-184 played a role in the chemo-sensitivity of PC-12/Dox cells at least partially via negatively regulating ADAM22. These results suggested miR-184 as a possible novel target to attenuate the chemo-resistance of PCC.
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