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Dohyun Ahn,Yunhui Min,Feng Fang,Young-Ok Son,Inhae Kang 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Osteoarthritis (OA) is a most common joint degenerative disease in the elderly population is closely related to metabolic disorders. However, it is still unclear whether high fat and sucrose (HFHS), contributing to nonalcoholic fatty liver disease (NAFLD), would exacerbate pathology of OA. To investigate the impact of HFHS on OA, C57BL/6 male mice were divided into three groups: i) low-fat (LF, 10% kcal fat), ii) high-fat diet (HF, 60% kcal fat), or iii) HF with high sucrose as a drink (HFHS, 20%) for 12 weeks and OA was induced by surgical destabilization of the medial meniscus (DMM). With expect, most of the metabolic parameters were deteriorated by HFHS+DMM compared to the LF+DMM group. HFHS induced severe cartilage erosion with osteophyte development and subchondral bone plate thickening, which indicated HFHS diet exacerbated OA. These severities of OA were followed by elevated serum/hepatic cholesterol levels and hepatic inflammation in the HFHS+DMM group, compared to the LF+DMM group. However, adipocyte remodeling did not alter by HFHS. These findings indicated excessive consumption of the HFHS triggered hepatic inflammation in NAFLD, which contributes to OA’s progression.