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Yue Yifeng,Zong Liwu,Chen Yongmin,Nianhai Feng,Tang Junxia,Xu Hongyu,Zhao Meiling 대한독성 유전단백체 학회 2021 Molecular & cellular toxicology Vol.17 No.4
Background Inflammation and oxidative stress-induced molecular death are one of the important causes for lung injury in critically ill patients. LKB1 is an important protein kinase in the body and has regulated inflammation and oxidative stress. However, LKB1 control inflammation and oxidative stress in lung injury were unclear. Objective We aimed to investigate the function and mechanism of Liver kinase B1 (LKB1) in lipopolysaccharide (LPS)-induced lung injury. Result LKB1 prevented lung injury, and weakened correlation oxidative stress and inflammatory reaction in LPS-induced mice model of lung injury. Up-regulation of LKB1 reduced reactive oxygen species (ROS) production and it-induced oxidative stress, and weakened inflammatory reactions in LPS-induced lung injury A549 cells. Down-regulation of LKB1 increased ROS production and it-induced oxidative stress, and enhanced inflammatory reactions in LPS-induced lung injury A549 cells. LKB1 induced phosphorylation (p)-AMPK protein expression, and suppressed the protein expression of NLRP3 in LPS-induced mice model of lung injury and in LPS-induced lung injury A549 cells. This experiment demonstrated the inhibition of AMPK or activation of NLRP3 inflammasome reversed the anti-inflammation function of LKB1 in LPS-induced lung injury. Meanwhile, ROS-induced oxidative stress also participated in the anti-inflammation effects of LKB1 in LPS-induced lung injury. Conclusion Therefore, our results indicate that LKB1 reduced inflammation and oxidative stress by regulating the AMPK/NLRP3 signaling pathway in LPS-induced lung injury.
Conceptual design and RCS property research of three-surface strike fighter
Yue, Kuizhi,Tian, Yifeng,Liu, Hu,Han, Wei The Korean Society for Aeronautical and Space Scie 2014 International Journal of Aeronautical and Space Sc Vol.15 No.3
This paper mainly focuses on the conceptual design and stealth performance of the three-surface military aircraft. A three-dimensional (3-D) digital mock-up of the three-surface strike fighter with stealth feature was designed and the schemes of carrying missiles were analyzed in CATIA. Based on physical optics principle and the Method of Equivalent Currents (MEC), a numerical simulation of the RCS feature of the aircraft was carried out with RCSPlus which is a software designed by Beihang University. The paper contributes to the RCS feature analysis of the whole plane and different parts on X-band, S-band and UHF-band and a comparison of RCS feature to Su-37 and T-50 military aircraft is drawn. On X-band, the pitch angle of the incident wave was $0^{\circ}$, and the result shows: (1) Compared with Su-37 aircraft, the forward scattering RCS of the three-surface strike aircraft was reduced to 14.9%, the side scattering RCS to 9.6% and the back scattering RCS to 40.2%. (2) Compared with T-50 aircraft, the forward scattering RCS was reduced to 38.61%, and the side scattering RCS to 67.26%. This paper should be useful for researchers in conceptual design and stealth technology of the military aircraft.
Conceptual design and RCS property research of three - surface strike fighter
Kuizhi Yue,Yifeng Tian,Hu Liu,Wei Han 한국항공우주학회 2014 International Journal of Aeronautical and Space Sc Vol.15 No.3
This paper mainly focuses on the conceptual design and stealth performance of the three-surface military aircraft. A threedimensional (3-D) digital mock-up of the three-surface strike fighter with stealth feature was designed and the schemes of carrying missiles were analyzed in CATIA. Based on physical optics principle and the Method of Equivalent Currents (MEC), a numerical simulation of the RCS feature of the aircraft was carried out with RCSPlus which is a software designed by Beihang University. The paper contributes to the RCS feature analysis of the whole plane and different parts on X-band, S-band and UHF-band and a comparison of RCS feature to Su-37 and T-50 military aircraft is drawn. On X-band, the pitch angle of the incident wave was 0°, and the result shows: (1) Compared with Su-37 aircraft, the forward scattering RCS of the three-surface strike aircraft was reduced to 14.9%, the side scattering RCS to 9.6% and the back scattering RCS to 40.2%. (2) Compared with T-50 aircraft, the forward scattering RCS was reduced to 38.61%, and the side scattering RCS to 67.26%. This paper should be useful for researchers in conceptual design and stealth technology of the military aircraft.
Juan Du,Lei Liu,Yifeng Yu,Yue Zhang,Aibing Chen 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.76 No.-
A self-assembly method using ionic liquids as soft-template and nitrogen precursor, resin as carbonprecursor, silica as assistant agent, mesoporous resin spheres as additive, is employed to prepare Ndopedcore–shell mesoporous sphere and carbon sheet composite (N-CMCS/CS). The obtained N-CMCS/CS possesses thin sheet, core–shell spheres, dual-mesoporous structure, large specific area and a certainof N-doping, which endows it with superior electrochemical performance as electrode material insupercapacitor.