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Bak, Seong-Min,Nam, Kyung-Wan,Chang, Wonyoung,Yu, Xiqian,Hu, Enyuan,Hwang, Sooyeon,Stach, Eric A.,Kim, Kwang-Bum,Chung, Kyung Yoon,Yang, Xiao-Qing American Chemical Society 2013 Chemistry of materials Vol.25 No.3
<P>In this work, we present results from the application of a new in situ technique that combines time-resolved synchrotron X-ray diffraction and mass spectroscopy. We exploit this approach to provide direct correlation between structural changes and the evolution of gas that occurs during the thermal decomposition of (over)charged cathode materials used in lithium-ion batteries. Results from charged Li<SUB><I>x</I></SUB>Ni<SUB>0.8</SUB>Co<SUB>0.15</SUB>Al<SUB>0.05</SUB>O<SUB>2</SUB> cathode materials indicate that the evolution of both O<SUB>2</SUB> and CO<SUB>2</SUB> gases are strongly related to phase transitions that occur during thermal decomposition, specifically from the layered structure (space group <I>R</I>3̅<I>m</I>) to the disordered spinel structure (<I>Fd</I>3̅<I>m</I>), and finally to the rock-salt structure (<I>Fm</I>3̅<I>m</I>). The state of charge also significantly affects both the structural changes and the evolution of oxygen as the temperature increases: the more extensive the charge, the lower the temperature of the phase transitions and the larger the oxygen release. Ex situ X-ray absorption spectroscopy (XAS) and in situ transmission electron microscopy (TEM) are also utilized to investigate the local structural and valence state changes in Ni and Co ions, and to characterize microscopic morphology changes. The combination of these advanced tools provides a unique approach to study fundamental aspects of the dynamic physical and chemical changes that occur during thermal decomposition of charged cathode materials in a systematic way.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/cmatex/2013/cmatex.2013.25.issue-3/cm303096e/production/images/medium/cm-2012-03096e_0014.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cm303096e'>ACS Electronic Supporting Info</A></P>
Sun, Chang-Qing,Chang, Yu-Bo,Cui, Ling-Ling,Chen, Jia-Jun,Sun, Nan,Zhang, Wei-Jie,Jia, Xiao-Can,Tian, Yuan,Dai, Li-Ping Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5
Gastric cancer is the second most common cause of cancer-related deaths in the world. Although certain dietary factors and lifestyles have been suggested to be associated with gastric carcinogenesis, there have been few investigations focusing on rural areas. A case-control study was therefore carried out to investigate the risk factors of gastric cardia cancer (GCC) in rural areas of Linzhou. A total of 470 newly diagnosed cases of GCC and 470 healthy controls were included. Face-to-face interviews were conducted, using a uniform questionnaire containing questions on demographics, per capita income, living habits, dietary habits and family history of tumors. The relationship between putative risk factors and GCC was assessed by odds ratios (OR) and their 95% confidence intervals (95%CI) derived from conditional logistic regression model by the COXREG command using SPSS 12.00. Multivariate logistic regression analysis was used to evaluate simultaneously the effects of multiple factors and other potential confounding factors. Multivariate logistic analysis showed that smoking (OR=1.939, 95%CI:1.097-3.426), alcohol drinking (OR=2.360, 95%CI: 1.292-4.311), hot food consumption (OR=2.034, 95%CI: 1.507-2.745), fast eating (OR=1.616, 95%CI: 1.171-2.230), mouldy food (OR=4.564, 95%CI: 2.682-7.767), leftover food (OR=1.881. 95%CI: 1.324-2.671), and family history of tumor (OR=2.831, 95%CI: 1.588-5.050) were risk factors for GCC. High per capita income (OR=0.709, 95%CI: 0.533-0.942), high education level (OR=0.354, 95%CI: 0.163-0.765), consumption of fresh fruits (OR=0.186, 95%CI: 0.111-0.311) and vegetables (OR=0.243, 95%CI: 0.142-0.415), and high BMI (OR=0.367, 95%CI: 0.242-0.557) were protective factors for GCC. Our data indicate that unhealthy lifestyle and dietary habits might be important contributors to GCC in this population.
Synthesis and In Vitro Cytotoxicity of Cis-[Pt(NH3)(NH2OH)Cl2]
Qing-Song Ye,Xi-Zhu Chen,Yao Yu,Qiao-Wen Chang,Shu-Qian Hou,Wei-Ping Liu 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.6
A novel mixed NH3/NH2OH platinum(II) complex cis-[Pt(NH3)(NH2OH)Cl2] was synthesized and characterized by elemental analysis, FAB-MS, FT-IR and 1H NMR spectroscopy. This complex was determined to have a good water-solubility and satisfactory stability. The pertinent complex was evaluated for its in vitro cytotoxicity against 3AO, HCT-116, LNcap, A549/ATCC and SGC-7901 human carcinoma cell lines. It shows appreciable cytotoxic activity that is comparable with cisplatin and is much more active than carboplatin.
InSAR-based Glacier Velocity Mapping in the Parlung Zangbo River Basin, Tibetan Plateau, China
Chang-Qing Ke,이훈열,Lan-Yu Li 대한원격탐사학회 2019 大韓遠隔探査學會誌 Vol.35 No.1
By applying the method of SAR interferometry to X-band synthetic aperture radar (SAR) image of COSMO-SkyMed, detailed motion patterns of five glaciers in the Parlung Zangbo River basin, Tibetan Plateau, in January 2010 have been derived. The results indicate that flow patterns are generally constrained by the valley geometry and terrain complexity. The maximum of 123.9 ma-1 is observed on glacier No.1 and the minimum of 39.4 ma-1 is found on glacier No.3. The mean values of five glaciers are between 22.9 and 98.2 ma-1. Glaciers No.1, No.2, No.4 and No.5 exhibit high velocities in their upper sections with big slope and low velocities in the lower sections. A moraine lake accelerates the speed of mass exchange leading to a fast flow at the terminal of glacier No.3. These glaciers generally move along the direction of decreased elevation and present a macroscopic illustration of the motion from the northwest to the southeast. The accuracy of DEM and registration conditions of DEMsimulated terrain phases has certain effects on calculations of glacier flow direction and velocity. The error field is relatively fragmented in areas inconsistent with the main flow line of the glaciers, and the shape and uniformity of glacier are directly related to the continuous distribution of flow velocity errors.
Guo, Yu,Xu, Li-Sha,Zhang, Ding,Liao, Ya-Ping,Wang, Hai-ping,Lan, Zhi-Hui,Guan, Wei-Jun,Liu, Chang-Qing Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8
Objectives: To investigate the effects of betaine on HeLa cell growth and apoptosis and molecular mechanisms. Materials and Methods: Concentrations of 0.1, 1.0, 5.0, 20.0, 100.0 mg/ml of betaine were used to evaluate the anticancer efficacy for HeLa cells respectively, and MCF-10A was also detected as a normal diploid cell control. Results: We found that proliferation of HeLa cells was inhibited significantly upon exposure to increasing betaine levels with the MTT test (p<0.05). The percentage of S phase cells in the low dose groups (<5mg/ml) were distinctly higher than in high dose groups, and the rates of Sub-G1 phase were the opposite (p<0.01); A high concentration of betaine (>5.0mg/ml) significantly promoted the apoptosis of HeLa cells (p<0.01). SOD activities of the low dose groups were slightly higher than the control group (p<0.05) and there were obvious synchronicity and correlation among the expression of promoting apoptosis genes Bax, P53, Caspase 3 and apoptosis suppression gene Bcl-2. In response to an apoptosis-inducing stimulus, p53 and cyclin D1 could be activated with blockage of the cell cycle at G1/S or S/G2 checkpoints. Conclusions: Our data showed that betaine could promote HeLa cells proliferation in vitro at low concentrations. In contrast, high concentrations could significantly inhibit cell growth and migration, and induce apoptosis of HeLa cells through caspase 3 signaling and further promoted necrosis. This might imply that betaine exhibits tumoricidal effects and acts as a biological response modifier in cancer treatment by inducing apoptosis and cell cycle arrest in a dose and time-dependent manner.
InSAR-based Glacier Velocity Mapping in the Parlung Zangbo River Basin, Tibetan Plateau, China
Ke, Chang-Qing,Lee, Hoonyol,Li, Lan-Yu The Korean Society of Remote Sensing 2019 大韓遠隔探査學會誌 Vol.35 No.1
By applying the method of SAR interferometry to X-band synthetic aperture radar (SAR) image of COSMO-SkyMed, detailed motion patterns of five glaciers in the Parlung Zangbo River basin, Tibetan Plateau, in January 2010 have been derived. The results indicate that flow patterns are generally constrained by the valley geometry and terrain complexity. The maximum of $123.9ma^{-1}$ is observed on glacier No.1 and the minimum of $39.4ma^{-1}$ is found on glacier No.3. The mean values of five glaciers are between 22.9 and $98.2ma^{-1}$. Glaciers No.1, No.2, No.4 and No.5 exhibit high velocities in their upper sections with big slope and low velocities in the lower sections. A moraine lake accelerates the speed of mass exchange leading to a fast flow at the terminal of glacier No.3. These glaciers generally move along the direction of decreased elevation and present a macroscopic illustration of the motion from the northwest to the southeast. The accuracy of DEM and registration conditions of DEM-simulated terrain phases has certain effects on calculations of glacier flow direction and velocity. The error field is relatively fragmented in areas inconsistent with the main flow line of the glaciers, and the shape and uniformity of glacier are directly related to the continuous distribution of flow velocity errors.
Guo, Yu,Liao, Ya-Ping,Zhang, Ding,Xu, Li-Sha,Li, Na,Guan, Wei-Jun,Liu, Chang-Qing Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5
Although nucleolar protein nucleostemin (NS) is essential for cell proliferation and early embryogenesis and expression has been observed in some types of human cancer and stem cells, the molecular mechanisms involved in mediation of cell proliferation and cell cycling remains largely elusive. The aim of the present study was to evaluate NS as a potential target for gene therapy of human breast carcinoma by investigating NS gene expression and its effects on SKBR-3 cell proliferation and apoptosis. NS mRNA and protein were both found to be highly expressed in all detected cancer cell lines. The apoptotic rate of the pcDNA3.1-NS-Silencer group ($12.1-15.4{\pm}3.8%$) was significantly higher than those of pcDNA3.1-NS ($7.2-12.0{\pm}1.7%$) and non-transfection groups ($4.1-6.5{\pm}1.8%$, P<0.01). MTT assays showed the knockdown of NS expression reduced the proliferation rate of SKBR-3 cells significantly. Matrigel invasion and wound healing assays indicated that the number of invading cells was significantly decreased in the pcDNA3.1-NS-siRNA group (P<0.01), but there were no significant difference between non-transfected and over-expression groups (P>0.05). Moreover, RNAi-mediated NS down-regulation induced SKBR-3 cell G1 phase arrest, inhibited cell proliferation, and promoted p53 pathway-mediated cell apoptosis in SKBR-3 cells. NS might thus be an important regulator in the G2/M check point of cell cycle, blocking SKBR-3 cell progression through the G1/S phase. On the whole, these results suggest NS might be a tumor suppressor and important therapeutic target in human cancers.