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Wi, Youngjin,Le, Hoa Thi,Verwilst, Peter,Sunwoo, Kyoung,Kim, Seo Jin,Song, Jung Eun,Yoon, Hey Young,Han, Geon,Kim, Jong Seung,Kang, Chulhun,Kim, Tae Woo The Royal Society of Chemistry 2018 Chemical communications Vol.54 No.64
<P>We synthesized a fluorogenic disulfide-based naphthalimide thiol probe (ER-Naph) with a hydrophilic endoplasmic reticulum (ER)-guiding glibenclamide unit. Its ER targeting ability and high selectivity to GSH over thioredoxin, a potent competitor, were clearly demonstrated, both in solution and <I>in vitro</I>. Finally, a confocal microscopic investigation revealed that GSH levels in the ER were dramatically decreased under thapsigargin, brefeldin A, and tunicamycin-induced ER stress models.</P>
Lee, Hoyeon,Yang, Zhigang,Wi, Youngjin,Kim, Tae Woo,Verwilst, Peter,Lee, Yun Hak,Han, Ga-in,Kang, Chulhun,Kim, Jong Seung American Chemical Society 2015 Bioconjugate chemistry Vol.26 No.12
<P>An endoplasmic reticulum (ER) membrane-selective chemosensor composed of BODIPY and coumarin moieties and a long alkyl chain (<I>n</I>-C18) was synthesized. The emission ratio of BODIPY to coumarin depends on the solution viscosity. The probe is localized to the ER membrane and was applied to reveal the reduced ER membrane fluidity under ER stress conditions.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bcches/2015/bcches.2015.26.issue-12/acs.bioconjchem.5b00508/production/images/medium/bc-2015-00508q_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/bc5b00508'>ACS Electronic Supporting Info</A></P>