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1
An Analysis of the Effects of University Freshmen's Extracurricular Programs for the Public Value

Seohyun Song(Seohyun Song),Younghee Pyo(Younghee Pyo),Jongpil Lee(Jongpil Lee) J-INSTITUTE 2022 Public Value Vol.7 No.2
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Purpose: The purpose of this study is to provide the basic data for the operation of the extracurricular program by examining whether it is effective for university life adjustment and student competency improvement accord-ing to the motivation to participate in the extracurricular program and the participation in the extracurricular program. Method: As for the data collection, a survey was conducted with freshmen in the natural science department of O University O located in in the metropolitan area. 1. To analyze as to whether the motivation for participation in the extracurricular program has an effect on the university life adjustment, the validity of the motivation to participate and the university life adaptation fac-tors was verified, then the inter-individual effect was verified. 2. Group statistics were analyzed to analyze as to whether the participation in the extracurricular program has an effect on the university freshmen's adaptation to the university life. 3. To verify the effect of participation in the extracurricular program and the student competency enhance-ment, the O University’s 5L Core Competency Diagnostic Tool(2021) was used, and the competency evaluation scores for the 4 competencies except for L3 were compared on an ex ante and ex post basis. Results: The motivation to participate in the extracurricular program for Research Question 1 was verified to have an effect on the university freshmen's adaptation to the university life, and consequently, it was apparent that motivation is more important before publicity or program improvement for the participation in extracurric-ular program. As a result of analysis as to whether to participate in the extracurricular program for Research Question 2 and the university life adjustment of freshmen, the participation in the extracurricular program was effective for all questions about university life adaptation. As a result of analyzing the effect of the extracurricular program for Research Question 3, it was apparent that the extracurricular program related to the auditory per-sonality competency L1, future learning competency L2, and job-based competency L3 was effective in enhancing the student competency, and it is considered that the extracurricular program related to the competency L5 needs to be improved for quality control to strengthen the student competency. Conclusion: This study was conducted with freshmen in the natural science department, and hence, there are limitations to generalizing to all university students. In the future studies, if factors such as segmentation by category and program learning efficacy are considered together, it will be possible to present a more specific way to activate the extracurricular program.
2
Contribution of HSP90 Cleavage to the Cytotoxic Effect of Suberoylanilide Hydroxamic Acid In Vivo and the Involvement of TXNIP in HSP90 Cleavage

( Sangkyu Park ),( Dongbum Kim ),( Haiyoung Jung ),( In Pyo Choi ),( Hyung-joo Kwon ),( Younghee Lee ) 한국응용약물학회 2024 Biomolecules & Therapeutics(구 응용약물학회지) Vol.32 No.1
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  ScienceON
  
  KISS
Heat shock protein (HSP) 90 is expressed in most living organisms, and several client proteins of HSP90 are necessary for cancer cell survival and growth. Previously, we found that HSP90 was cleaved by histone deacetylase (HDAC) inhibitors and proteasome inhibitors, and the cleavage of HSP90 contributes to their cytotoxicity in K562 leukemia cells. In this study, we first established mouse xenograft models with K562 cells expressing the wild-type or cleavage-resistant mutant HSP90β and found that the suppression of tumor growth by the HDAC inhibitor suberoylanilide hydroxamic acid (SAHA) was interrupted by the mutation inhibiting the HSP90 cleavage in vivo. Next, we investigated the possible function of thioredoxin interacting protein (TXNIP) in the HSP90 cleavage induced by SAHA. TXNIP is a negative regulator for thioredoxin, an antioxidant protein. SAHA transcriptionally induced the expression of TXNIP in K562 cells. HSP90 cleavage was induced by SAHA also in the thymocytes of normal mice and suppressed by an anti-oxidant and pan-caspase inhibitor. When the thymocytes from the TXNIP knockout mice and their wild-type littermate control mice were treated with SAHA, the HSP90 cleavage was detected in the thymocytes of the littermate controls but suppressed in those of the TXNIP knockout mice suggesting the requirement of TXNIP for HSP90 cleavage. We additionally found that HSP90 cleavage was induced by actinomycin D, β-mercaptoethanol, and p38 MAPK inhibitor PD169316 suggesting its prevalence. Taken together, we suggest that HSP90 cleavage occurs also in vivo and contributes to the anti-cancer activity of various drugs in a TXNIP-dependent manner.
3
공통선 신호망을 위한 집중관리 방식의 설계

남택용(Taekyong Nam),김미순(Misoon Kim),궁상환(Sanghwan Kung),이영희(Younghee Lee),홍진표(Jun Pyo Hong) 한국정보과학회 1990 한국정보과학회 학술발표논문집 Vol.17 No.2
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The paper describes an operations system newly designed to establish the network management and provisioning functions for CCS(Common Channel Signaling) network, being currently deployed in Korea. SIGNOS(Signaling Network Operations System), which is a sort of centralized system to accommodate a number of SMX-Is(Signaling Message Exchange), so called STP, consistently monitors and maintains CCS network in the network wide view to assure efficient utilization of the network In the paper, the system architecture and functions of SIGNOS are mainly concerned and, as a introductory remarks, the fundamental concepts of CCS network and its applicable areas referred to related CCITT recommendations are also mentioned.