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Yongfen Ma,Jae-Yeon Jung,Yu-Jung Jung,Ji-Hye Choi,Woo-Sik Jeong,Young-Sun Song,Jae-Seon Kang,Kaishun Bi,Myo-Jeong Kim 한국식품영양과학회 2009 Preventive Nutrition and Food Science Vol.14 No.3
Five kinds of coumarin compounds were successfully purified from Angelica gigas Nakai by using recyclingpreparative HPLC and identified as decursin (1), decursinol angelate (2), 7-demethylsuberosine (3), marmesin (4), and decursinol (5) by NMR analyses. None of the purified compounds in ethanol showed DPPH radical scavenging activity, while the A. gigas extract (AGNEX) displayed a significant level of activity. Interestingly, compounds 3 in phosphate buffered saline (PBS) showed good ABTS<SUP>+</SUP> radical scavenging activity (IC50=8.1 ㎍/mL) as did compounds 4 and 5. The anti-inflammatory activities of the purified compounds were evaluated and compared using the NO concentration assay and western blot analysis on LPS-stimulated RAW 264.7 cells. NO production was significantly suppressed by all the compounds in a dose-dependent manner among which compounds 1, 2, and 3 showed very good activities with IC50 values of 7.4, 6.5, and 7.6 ㎍/mL, respectively. Treatment with compounds 1-5 effectively suppressed the expression levels of iNOS, IL-1β, and COX-2, which are responsible for promoting the inflammatory process. Thus, the ethanol extract and coumarin compounds of A. gigas Nakai hold promise for use as potential anti-inflammatory agents.
Distinguish Method of Failure on Reinforced Concrete Frame Buildings with Masonry Infill Walls
Jiang, Fan,Yan, Tao,Yongfen, Ruan 대한금속재료학회(대한금속학회) 1998 METALS AND MATERIALS International Vol.4 No.4
In the past researches, the influence of the weigh for the masonry infill walls on reinforced concrete frame was only considered in the calculation of the structure for the reinforced concrete frame buildings with masonry infill walls, the action o1' lateral resistant thrust of the masonry infill walls to reinforced concrete frame was usually neglected. A large of model experiments, theoretical analyses and investigations for the damage due to earthquake have been shown that reinforced concrete frame buildings with the masonry infill walls can not only raise the lateral resistant thrust of whole structure, but also put off the production of plastic hinge and raise the bearing capacity of whole structure. In this paper, a mixed element model was made up of the element for reinforced concrete frame bar and the plane element for masonry infill wall, This model, which was loaded by the statically admissible in groups horizontal load P and the identical vertical load was analyzed. The bending moments M_c on the column ends was obtained. The limited bending moments M_(cy) was calculated under the given stiffness, reinforcement bar and ratio of axial pressure. From the calculation and comparison, the distinguish conditions of plastic failure under various the masonry infill walls and different stiffness mere obtained, the mechanism of the plastic hinges on the frame was discussed.