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Yong Zhu,Tao Lu,Xin Chen,Zeng Wu,Yixuan Zheng,Yadong Chen,Weifang Tang 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.10
A series of diaryl ether hydroxamic acids were synthesized for the first time and evaluated for the HDAC biology and antiproliferative activity. The structures of these new hydroxamic acids derivatives were confirmed by IR, 1H-NMR and mass spectrum. Some of these compounds showed micro molar activity in the HDAC inhibitory assay and against four cancer cell lines.