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Zhan, Yingzhuan,Chen, Yinnan,Liu, Rui,Zhang, Han,Zhang, Yanmin 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.8
It has been suggested that combined effect of natural products may improve the treatment effectiveness in combating proliferation of cancer cells. Here, we examined the combined anticancer activities of compounds of three natural origin including baicalein, curcumin, and resveratrol with chemotherapy drug paclitaxel respectively, which showed that combination of paclitaxel with curcumin exhibited synergistic growth inhibition and induced significant apoptosis in MCF-7 cell lines. Treatment of MCF-7 cell lines with paclitaxel and curcumin induced the apoptosis of regulatory protein Bcl-2 but decreased Bax expression. In addition, simultaneous treatment with paclitaxel and curcumin strongly inhibited paclitaxel-induced activities of EGFR signaling. Furthermore, the combination of paclitaxel and curcumin exerted increased anti-tumor efficacy on mouse models. Overall, our data described the promising therapeutic potential and underlying mechanisms of combining paclitaxel with curcumin in treating breast cancer.
Yingzhuan Zhan,Yinnan Chen • Rui Liu,Han Zhang,Yanmin Zhang 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.8
It has been suggested that combined effect ofnatural products may improve the treatment effectiveness incombating proliferation of cancer cells. Here, we examinedthe combined anticancer activities of compounds of threenatural origin including baicalein, curcumin, and resveratrolwith chemotherapy drug paclitaxel respectively, whichshowed that combination of paclitaxel with curcuminexhibited synergistic growth inhibition and induced significantapoptosis in MCF-7 cell lines. Treatment of MCF-7cell lines with paclitaxel and curcumin induced the apoptosisof regulatory protein Bcl-2 but decreased Baxexpression. In addition, simultaneous treatment with paclitaxeland curcumin strongly inhibited paclitaxel-inducedactivities of EGFR signaling. Furthermore, the combinationof paclitaxel and curcumin exerted increased anti-tumorefficacy on mouse models. Overall, our data described thepromising therapeutic potential and underlying mechanismsof combining paclitaxel with curcumin in treating breast cancer.