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RISS 인기검색어
- 검색키워드
- 저자 : Yinglong Huang (검색결과 2 건)
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ox-LDL regulates proliferation and apoptosis in VSMCs by controlling the miR-183-5p/FOXO1
Fan Mingqiang,Huang Yinglong,Li Kunsheng,Yang Xiangxiang,Bai Jing,Si Qiaoke,Peng Zhengfei,Jia Chunwen,Zhang Qiangnu,Tao Ding 한국유전학회 2022 Genes & Genomics Vol.44 No.6
Background: microRNA-mRNA axes that are involved in oxidized low-density lipoprotein (ox-LDL)-induced vascular smooth muscle cells (VSMCs) proliferation/apoptosis imbalance need to be further investigated. Objective: To investigate the functional role of miR-183-5p/FOXO1 in VSMCs and its interaction with ox-LDL. Methods: RNA sequencing was used to detect transcriptome changes of VSMCs treated with ox-LDL. miR-183-5p and FOXO1 expression levels in VSMCs after ox-LDL treatment were assessed using qRT-PCR and western blotting. The regulatory effect of miR-183-5p on FOXO1 has been tried to prove using a dual-luciferase reporter assay. The functions of miR-183-5p, and FOXO1 were analyzed by CCK-8 assay and flow cytometry assay. The tissue samples or serum samples of high fat-feeding mice and carotid atherosclerosis patients were collected, and the levels of miR-183-5p/FOXO1 were analyzed. Results: RNA sequencing data showed 81 miRNAs including miR-183-5p was significantly changed after ox-LDL treatment in VSMCs. FOXO1, a miR-183-5p's potential target, was also down-regulated in ox-LDL treated cells. qRT-PCR and western blot found that expression of FOXO1 mRNA and protein significantly reduced in VSMCs treated with ox-LDL, accompanied by overexpression of miR-183-5p. miR-183-5p inhibited FOXO1 mRNA by binding to its 3' UTR. Interference miR-183-5p/FOXO1 could change proliferation/apoptosis imbalance in VSMCs under ox-LDL stimulation. Higher levels of miR-183-5p but reduced FOXO1 can be found in the thoracic aorta tissues of high fat-feeding mice. In serum samples from individuals with carotid atherosclerosis, Higher levels of miR-183-5p were observed. the miR-183-5p level was positively related to the level of serum ox-LDL in patients. Conclusions: Aberrant expression of miR-183-5p/FOXO1 pathway mediated ox-LDL-induced proliferation/apoptosis imbalance in VSMCs. The miR-183-5p/FOXO1 axis can potentially be utilized as the target in the treatment of patients with atherosclerosis.
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Development of a 97.5-inch Super Hi-Vision 8K × 4K liquid crystal display panel
Yanping Liao,Xibin Shao,Jianfeng Yuan,Xiqing Zhang,Ji Zhang,Changlin Leng,Yinglong Huang,Seongkuy Lee 한국정보디스플레이학회 2015 Journal of information display Vol.16 No.3
A prototype 97.5-inch 8K×4K a-Si liquid crystal display (LCD) panel for Super Hi-Vision with ultra-high definition was successfully developed using the BOE exclusive advanced super-dimensional switching technology. This LCD has a panel with 7680(×3) by 4320 pixels, 16 times those of the conventional Full High Definition (FHD), and the pixel size of the panel is 0.2811mm (90.4 pixels per inch). The liquid crystal charging time was extended by quad area and double source line structure (also called “2G2D driving”). Additionally, a multi-functional image-processing video board was developed to compatibly realize the real-time display of huge image data from FHD to 8K. Furthermore, the reason for the arcing that occurred in half-tone source–drain mask etching was discussed and was ultimately solved by improving the exposure process. The demonstrated panel features a 1200:1 contrast ratio, 500 nit brightness, and 72% color gamut.
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