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67-fs pulse generation from a mode-locked Tm,Ho:CLNGG laser at 2083 nm
Zhao, Yongguang,Wang, Yicheng,Chen, Weidong,Pan, Zhongben,Wang, Li,Dai, Xiaojun,Yuan, Hualei,Zhang, Yan,Cai, Huaqiang,Bae, Ji Eun,Choi, Sun Young,Rotermund, Fabian,Loiko, Pavel,Serres, Josep Maria,Mat The Optical Society 2019 Optics express Vol.27 No.3
78 fs SWCNT-SA mode-locked Tm:CLNGG disordered garnet crystal laser at 2017 nm
Wang, Yicheng,Zhao, Yongguang,Pan, Zhongben,Bae, Ji Eun,Choi, Sun Young,Rotermund, Fabian,Loiko, Pavel,Serres, Josep Maria,Mateos, Xavier,Yu, Haohai,Zhang, Huaijin,Mero, Mark,Griebner, Uwe,Petrov, Val The Optical Society 2018 Optics letters Vol.43 No.17
Xi Hu,Yicheng Zhao,Yang Huang,Chen Zhu,Jun Yao,Nana Fang 한국인터넷정보학회 2022 KSII Transactions on Internet and Information Syst Vol.16 No.11
In urban vehicular edge computing (VEC) environments, one edge server always serves many task requests in its coverage which results in the resource-constrained problem. To resolve the problem and improve system utilization, we first design a general hierarchical resource management framework based on typical VEC network structures. Following the framework, a specific interacting protocol is also designed for our decision algorithm. Secondly, a greedy bidding-based multi-hop task scheduling decision algorithm is proposed to realize effective task scheduling in resource-constrained VEC environments. In this algorithm, the goal of maximizing system utility is modeled as an optimization problem with the constraints of task deadlines and available computing resources. Then, an auction mechanism named greedy bidding is used to match task requests to edge servers in the case of multiple hops to maximize the system utility. Simulation results show that our proposal can maximize the number of tasks served in resource constrained VEC networks and improve the system utility.
Sub-80 fs mode-locked Tm,Ho-codoped disordered garnet crystal oscillator operating at 2081 nm
Pan, Zhongben,Wang, Yicheng,Zhao, Yongguang,Kowalczyk, Maciej,Sotor, Jarosław,Yuan, Hualei,Zhang, Yan,Dai, Xiaojun,Cai, Huaqiang,Bae, Ji Eun,Choi, Sun Young,Rotermund, Fabian,Loiko, Pavel,Serres, Jose The Optical Society 2018 Optics letters Vol.43 No.20
( Ye Tao ),( Dazhong Sun ),( Xinran Ren ),( Yicheng Zhao ),( Hengjian Zhang ),( Tao Jiang ),( Jiyu Guan ),( Yong Tang ),( Wu Song ),( Shuqiang Li ),( Li Wang ) 한국미생물생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.10
Staphylococcus aureus (S. aureus) infection causes dramatic harm to human health as well as to livestock development. As an important virulence factor, alpha-hemolysin (hla) is critical in the process of S. aureus infection. In this report, we found that bavachin, a natural flavonoid, not only efficiently inhibited the hemolytic activity of hla, but was also capable of inhibiting it on transcriptional and translational levels. Moreover, further data revealed that bavachin had no neutralizing activity on hla, which did not affect the formation of hla heptamers and exhibited no effects on the hla thermal stability. In vitro assays showed that bavachin was able to reduce the S. aureus-induced damage of A549 cells. Thus, bavachin repressed the lethality of pneumonia infection, lung bacterial load and lung tissue inflammation in mice, providing potent protection to mice models in vivo. Our results indicated that bavachin has the potential for development as a candidate hla inhibitor against S. aureus.
Yifan Wang,Hao Wei,Zhen Song,Liqun Jiang,Mi Zhang,Xiao Lu,Wei Li,Yuqing Zhao,Lei Wu,Shuxian Li,Huijuan Shen,Qiang Shu,Yicheng Xie 고려인삼학회 2024 Journal of Ginseng Research Vol.48 No.1
Background: Lung inflammation occurs in many lung diseases, but has limited effective therapeutics. Ginseng andits derivatives have anti-inflammatory effects, but their unstable physicochemical and metabolic propertieshinder their application in the treatment. Panaxadiol (PD) is a stable saponin among ginsenosides. Inhalationadministration may solve these issues, and the specific mechanism of action needs to be studied. Methods: A mouse model of lung inflammation induced by lipopolysaccharide (LPS), an in vitro macrophageinflammation model, and a coculture model of epithelial cells and macrophages were used to study the effectsand mechanisms of inhalation delivery of PD. Pathology and molecular assessments were used to evaluate efficacy. Transcriptome sequencing was used to screen the mechanism and target. Finally, the efficacy andmechanism were verified in a human BALF cell model. Results: Inhaled PD reduced LPS-induced lung inflammation in mice in a dose-dependent manner, includinginflammatory cell infiltration, lung tissue pathology, and inflammatory factor expression. Meanwhile, the dose ofinhalation was much lower than that of intragastric administration under the same therapeutic effect, which maybe related to its higher bioavailability and superior pharmacokinetic parameters. Using transcriptome analysisand verification by a coculture model of macrophage and epithelial cells, we found that PD may act by inhibitingTNFA/TNFAR and IL7/IL7R signaling to reduce macrophage inflammatory factor-induced epithelial apoptosisand promote proliferation. Conclusion: PD inhalation alleviates lung inflammation and pathology by inhibiting TNFA/TNFAR and IL7/IL7Rsignaling between macrophages and epithelial cells. PD may be a novel drug for the clinical treatment of lunginflammation.