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Maltitol Prevents the Progression of Fatty Liver Degeneration in Mice Fed High-Fat Diets
Hayato Urushima,Yasuaki Sanada,Miki Sakaue,Yuji Matsuzawa,Toshinori Ito,Kazuhisa Maeda 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.10
Nonalcoholic fatty liver disease (NAFLD) progresses to nonalcoholic steatohepatitis, ultimately leading tocirrhosis and liver cancer. It is important to prevent this progression during the initial stages of hepatic fatty degeneration. Maltitol is a polyol produced by the hydrogenation of maltose. We investigated the efficacy of maltitol for treating hepaticfatty degeneration in C57BL/6 male mice using a high-fat diet model. Intake of 5.0% maltitol for 8 weeks significantlysuppressed weight gain, hepatic fatty degeneration, hyperglycemia, and hypercholesterolemia. With maltitol intake, sterolregulatory element-binding protein 1c (SREBP1c) mRNA expression was significantly decreased, and farnesoid X receptor(FXR), peroxisome proliferator-activated receptor α (PPARα), and hydroxymethylglutaryl-Co reductase expressions weresignificantly higher in the liver. The increase in SREBP1c and suppression of FXR and PPARa expressions are correlated withNAFLD. Our results suggest that maltitol may prevent steatosis of NAFLD with a high-fat diet.