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- 저자 : Yasin Bez (검색결과 2 건)
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Mehmet Cemal Kaya,Yasin Bez,Ibrahim Fatih Karababa,Ali Emhan,Nurten Aksoy,Mahmut Bulut,Mehmet Gunes,Abdullah Atli,Salih Selek 대한신경정신의학회 2013 PSYCHIATRY INVESTIGATION Vol.10 No.3
Objective In recent years, many published studies have focused on the relationship between oxidative stress and psychiatric disorders. However, studies in generalized anxiety disorder (GAD) are few despite relatively high prevalence rates. In an attempt to fill this gap in the literature we aimed to measure serum levels of free sulphydryl, an important member of antioxidant defense mechanisms, of the patients with GAD. Methods A total of 35 (23 female, 12 male) GAD patients without any other co-morbid medical or psychiatric disorder and 35 (23 female, 12 male) healthy controls have been included in the study. Disease severity of the patients were quantified by using the Hamilton Anxiety Rating Scale (HAM-A). Serum free sulphydryl group levels of patients and healthy controls were measured in an appropriate way. Results Mean level of serum sulphydryl groups was significantly lower in the patient group. There was a negative correlation between their level and the disease duration. However, they did not show any significant correlation with the disease severity. Conclusion Decreased serum sulphydryl level observed in pure GAD patients suggests an increased oxidative stress in these patients. Well designed future researches are needed to replicate our findings and to test the implications of the present study.
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Decreased Prolidase Activity in Patients with Posttraumatic Stress Disorder
Süleyman Demir,Mahmut Bulut,Abdullah Atli,I·brahim Kaplan,Mehmet Cemal Kaya,Yasin Bez,Pınar Güzel Özdemir,Aytekin Sır 대한신경정신의학회 2016 PSYCHIATRY INVESTIGATION Vol.13 No.4
ObjectiveaaMany neurochemical systems have been implicated in the development of Posttraumatic Stress Disorder (PTSD). The prolidase enzyme is a cytosolic exopeptidase that detaches proline or hydroxyproline from the carboxyl terminal position of dipeptides. Prolidase has important biological effects, and to date, its role in the etiology of PTSD has not been studied. In the present study, we aimed to evaluate prolidase activity in patients with PTSD. MethodsaaThe study group consisted of patients who were diagnosed with PTSD after the earthquake that occurred in the province of Van in Turkey in 2011 (n=25); the first control group consisted of patients who experienced the earthquake but did not show PTSD symptoms (n=26) and the second control group consisted of patients who have never been exposed to a traumatic event (n=25). Prolidase activities in the patients and the control groups were determined by the ELISA method using commercial kits. ResultsaaProlidase activity in the patient group was significantly lower when compared to the control groups. Prolidase activity was also significantly lower in the traumatized healthy subjects compared to the other healthy group (p<0.01). ConclusionaaThe findings of the present study suggest that the decrease in prolidase activity may have neuroprotective effects in patients with PTSD.
KCI
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