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Yanhua Bai,Kennichi Kakudo,정찬권 대한내분비학회 2020 Endocrinology and metabolism Vol.35 No.4
Advances in medical sciences and evidence-based medicine have led to momentous changes in classification and management of thyroid neoplasms. Much progress has been made toward avoiding overdiagnosis and overtreatment of thyroid cancers. The new 2017 World Health Organization (WHO) classification of thyroid neoplasms updated the diagnostic criteria and molecular and genetic characteristics reflecting the biology and behavior of the tumors, and newly introduced the category of borderline malignancy or uncertain malignant potential. Some neoplasms were subclassified, renamed, or redefined as a specific entity. This review introduces changes in the fourth edition WHO classification of thyroid tumors and updates the contemporary diagnosis and classification of thyroid tumors. We also discuss several challenges with the proposal of new diagnostic entities, since they have unique histopathologic and molecular features and clinical relevance.
Yanhua Ma,Rui Chen,Jiantao Bai,Wenjie Zuo 한국자동차공학회 2020 International journal of automotive technology Vol.21 No.2
At the conceptual design stage, the cross-sectional shapes of thin-walled beams (TWBs) need to be optimized to improve the performance of automobile structure. Therefore, this paper innovatively proposes a cross-sectional shape optimization method to acquire a low cost, high stiffness, manufacturable and lightweight TWB. Meanwhile, the stamping cost of thin-walled beams is analytically derived. The cross-sectional area is taken as the objective function to establish an optimization formulation with multiple constraints such as cross-sectional stiffness, manufacturability and cost of TWBs. The single-objective genetic algorithm based on non-dominant principle is introduced to solve the problem. The effectiveness of the proposed method is verified by an example of double cell cross-sectional shape.
( Suqin Shen ),( Jie Zuo ),( Huan Feng ),( Meirong Bai ),( Chenji Wang ),( Youheng Wei ),( Yanhong Li ),( Yichen Le ),( Jiaxue Wu ),( Yanhua Wu ),( Long Yu ) 생화학분자생물학회(구 한국생화학분자생물학회) 2016 BMB Reports Vol.49 No.6
T-complex protein 10A homolog 2 (TCP10L) was previously demonstrated to be a potential tumor suppressor in human hepatocellular carcinoma (HCC). However, little is known about the molecular mechanism. MAX dimerization protein 1 (MAD1) is a key transcription suppressor that is involved in regulating cell cycle progression and Myc-mediated cell transformation. In this study, we identified MAD1 as a novel TCP10L-interacting protein. The interaction depends on the leucine zipper domain of both TCP10L and MAD1. TCP10L, but not the interaction-deficient TCP10L mutant, synergizes with MAD1 in transcriptional repression, cell cycle G1 arrest and cell growth suppression. Mechanistic exploration further revealed that TCP10L is able to stabilize intracellular MAD1 protein level. Consistently, the MAD1-interaction-deficient TCP10L mutant exerts no effect on stabilizing the MAD1 protein. Taken together, our results strongly indicate that TCP10L stabilizes MAD1 protein level through direct interaction, and they cooperatively regulate cell cycle progression. [BMB Reports 2016; 49(6): 325-330]