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- 저자 : Yanagido, Ayana (검색결과 1 건)
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Yanagido, Ayana,Ueno, Mikinori,Jiang, Zedong,Cho, Kichul,Yamaguchi, Kenichi,Kim, Daekyung,Oda, Tatsuya Elsevier 2018 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.117 No.-
<P><B>Abstract</B></P> <P>The anti-inflammatory properties of porphyrans (D1–D4) obtained from four discolored nori (<I>Pyropia yezoensis</I>) with different growth backgrounds were studied to examine possible variations in their bioactivities. Elution profiles of the porphyrans on Sepharose 4B indicated that D2-porphyran had relatively lower-molecular-size porphyrans than the other porphyrans. Inhibitory activities of the four porphyrans against nitric oxide (NO) and tumor necrosis factor-α (TNF-α) secretion by lipopolysaccharide (LPS)-stimulated RAW264.7 cells were different, whereas no significant differences were observed in the sulfate and anhydrogalactose levels. D2-porphyran showed the highest inhibitory activity against NO and TNF-α secretion by LPS-stimulated RAW264.7 cells, whereas D3- and D4-porphyrans had almost no activity. All porphyrans were efficiently degraded by free radical generated with ascorbate and hydrogen peroxide. The free-radical degradation resulted in a significant increase in the inhibitory activities of the four porphyrans against NO and TNF-α secretion, with varying rates depending on the porphyrans. The ability of D2-porphyran to suppress the receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclastogenesis in RAW264.7 cells was also significantly enhanced after degradation. Our results suggest that molecular size is an important factor affecting the anti-inflammatory activity of porphyrans, and radical degradation might be a promising procedure to obtain active low-molecular-size porphyrans.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Molecular size distribution of porphyrans from discolored nori differ depending on the nori with different growth background. </LI> <LI> Anti-inflammatroy activity of the porphyrans are significantly different. </LI> <LI> Porphyran with lower molecular size tends to show higher anti-inflammatroy activity. </LI> <LI> All porphyrans are efficiently degraded by free radical generated with ascorbate and hydrogen peroxide. </LI> <LI> Radical degradation is promising procedure to obtain active low-molecular-size porphyrans, even from inactive porphyrans </LI> </UL> </P>
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