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Polygonumnolides A1–B3, minor dianthrone derivatives from the roots of Polygonum multiflorum Thunb
Jianbo Yang,Zheng Yan,Jin Ren,Zhong Dai,Shuangcheng Ma,Aiguo Wang,Yalun Su 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.6
Seven new dianthrone glycosides, named polygonumnolidesA1–B3 (1–7), were isolated from the 70 %EtOH extract of the dried roots of Polygonum multiflorumThunb. using column chromatography and preparativehigh-performance liquid chromatography. Their structureswere determined by 1D and 2D NMR and mass spectroscopy. The isolated compounds were evaluated for theircytotoxic effects against KB tumor cell lines and compounds1–4 showed moderate cytotoxicity.