Dose-Dense Rituximab-CHOP versus Standard Rituximab-CHOP in Newly Diagnosed Chinese Patients with Diffuse Large B-Cell Lymphoma: A Randomized, Multicenter, Open-Label Phase 3 Trial

Xueying Li,He Huang,Bing Xu,Hongqiang Guo,Yingcheng Lin,Sheng Ye,Jiqun Yi,Wenyu Li,Xiangyuan Wu,Wei Wang,Hongyu Zhang,Derong Xie,Jiewen Peng,Yabing Cao,Xingxiang Pu,Chengcheng Guo,Huangming Hong,Zhao 대한암학회 2019 Cancer Research and Treatment Vol.51 No.3

Purpose Rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone administered every 3 weeks (R-CHOP-21) is the standard care for diffuse large B-cell lymphoma (DLBCL). It is unknown whether the dose-dense R-CHOP (R-CHOP-14) could improve the outcome of the disease in Asian population. Materials and Methods Newly diagnosed DLBCL patients were centrally, randomly assigned (1:1) to receive R-CHOP- 14 or R-CHOP-21. R-CHOP-14 was administered every 2 weeks, and R-CHOP-21 was administered every 3 weeks. Primary end point was disease-free survival (DFS). Secondary end points included overall survival (OS), progression-free survival (PFS), response rate and toxicities. Results Seven hundred and two patients were randomly assigned to receive R-CHOP-14 (n=349) or R-CHOP-21 (n=353). With a median follow-up of 45.6 months, the two groups did not differ significantly in 3-year DFS (79.6% for R-CHOP-14 vs. 83.2% for R-CHOP-21, p=0.311), 3-year OS (77.5% for R-CHOP-14 vs. 77.6% for R-CHOP-21, p=0.903), or 3-year PFS (63.2% for R-CHOP-14 vs. 66.1% for R-CHOP-21, p=0.447). Patients with an International Prognostic Index (IPI) score ! 2 had a poorer prognosis compared to those with an IPI score < 2. Grade 3/4 hematologic and non-hematologic toxicities were manageable and similar between R-CHOP-14 and R-CHOP-21. Conclusion R-CHOP-14 did not improve the outcome of DLBCL compared to R-CHOP-21 in Asian population. With manageable and similar toxicities, both of the two regimens were suitable for Asian DLBCL patients. For high-risk patients with IPI ! 2, new combination regimens based on R-CHOP deserve further investigation to improve efficacy.

A Semantic Approach to the Design of Valid and Reversible Semistructured Views

Yabing Chen,Tok Wang Ling,Mong Li Lee,Masatake Nakanishi,Gillian Dobbie 한국정보과학회 2007 Journal of Computing Science and Engineering Vol.1 No.1

Existing systems that support semistructured views do not maintain semantics during the process of designing the views. Thus, these systems do not guarantee the validity and reversibility of the views. In this paper, we propose an approach to address the issue of valid and reversible semistructured views. We design a set of view operators for designing semistructured views. These operators are select, drop, join and swap. For each.operator, we develop a complete set of rules to maintain the semantics of the views. In particular, we maintain the evolution and integrity of relationships once an operator is applied. We also examine the reversible view problem under our operators and develop rules to guarantee that the designed views are reversible. Finally, we examine the changes in the participation constraints of relationship types during the view design process, and develop rules to ensure the correctness of the participation constraints.

A Semantic Approach to the Design of Valid and Reversible Semistructured Views

Chen, Yabing,Ling, Tok Wang,Lee, Mong Li,Nakanishi, Masatake,Dobbie, Gillian Korean Institute of Information Scientists and Eng 2007 Journal of Computing Science and Engineering Vol.1 No.1

Existing systems that support semistructured views do not maintain semantics during the process of designing the views. Thus, these systems do not guarantee the validity and reversibility of the views. In this paper, we propose an approach to address the issue of valid and reversible semistructured views, We design a set of view operators for designing semistructured views. These operators are select, drop, join and swap. For each operator, we develop a complete set of rules to maintain the semantics of the views. In particular, we maintain the evolution and integrity of relationships once an operator is applied. We also examine the reversible view problem under our operators and develop rules to guarantee that the designed views are reversible. Finally, we examine the changes in the participation constraints of relationship types during the view design process, and develop rules to ensure the correctness of the participation constraints.

Large eddy simulation of turbulent fl ow using the parallel computational fl uid dynamics code GASFLOW-MPI

Han Zhang,Yabing Li,Jianjun Xiao,Thomas Jordan 한국원자력학회 2017 Nuclear Engineering and Technology Vol.49 No.6

GASFLOW-MPI is a widely used scalable computational fluid dynamics numerical tool to simulate the fluidturbulence behavior, combustion dynamics, and other related thermalehydraulic phenomena in nuclearpower plant containment. An efficient scalable linear solver for the large-scale pressure equation is one ofthe key issues to ensure the computational efficiency of GASFLOW-MPI. Several advanced Krylov subspacemethods and scalable preconditioning methods are compared and analyzed to improve the computationalperformance. With the help of the powerful computational capability, the large eddy simulation turbulentmodel is used to resolve more detailed turbulent behaviors. A backward-facing step flow is performed tostudy the free shear layer, the recirculation region, and the boundary layer, which is widespread in manyscientific and engineering applications. Numerical results are compared with the experimental data in theliterature and the direct numerical simulation results by GASFLOW-MPI. Both time-averaged velocityprofile and turbulent intensity are well consistent with the experimental data and direct numericalsimulation result. Furthermore, the frequency spectrum is presented and a e5/3 energy decay is observedfor a wide range of frequencies, satisfying the turbulent energy spectrum theory. Parallel scaling tests arealso implemented on the KIT/IKET cluster and a linear scaling is realized for GASFLOW-MPI.

Landslide susceptibility mapping at Gongliu county, China using artificial neural network and weight of evidence models

Qiqing Wang,Wenping Li,Maolin Xing,Yanli Wu,Yabing Pei,Dongdong Yang,Hanying Bai 한국지질과학협의회 2016 Geosciences Journal Vol.20 No.5

The aim of this study was to apply and to verify the use of artificial neural network (ANN) and weight of evidence (WoE) models to landslide susceptibility mapping in the Gongliu county, China, using a geographic information system (GIS). For this aim, in this study, a landslide inventory map was prepared using earlier reports and aerial photographs as well as by carrying out field surveys. A total of 163 landslides (70% out of 233 detected landslides) were randomly selected for model training, and the remaining 70 landslides (30%) were used for the model validation. Then, a total number of twelve landslide conditioning factors, such as slope angle, slope aspect, general curvature, plan curvature, profile curvature, altitude, distance to rivers, distance to roads, lithology, rainfall, normalized difference vegetation index (NDVI), and sediment transport index (STI), were used in the analysis. Landslide hazardous areas were analyzed and mapped using the landslide-occurrence factors by ANN and WoE models. Finally the output maps were validated using the area under the curve (AUC) method. The validation results showed that the ANN model with a success rate of 82.51% and predictive accuracy of 77.31% performs better than WoE (success rate, 79.82%; predictive accuracy, 74.59%) model. Overall, both models showed almost similar results. Therefore, the two landslide susceptibility maps obtained were successful and can be useful for preliminary general land use planning and hazard mitigation purpose.

Real-Space Imaging of the Atomic Structure of Organic–Inorganic Perovskite

Ohmann, Robin,Ono, Luis K.,Kim, Hui-Seon,Lin, Haiping,Lee, Michael V.,Li, Youyong,Park, Nam-Gyu,Qi, Yabing American Chemical Society 2015 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.137 No.51

<P>Organic–inorganic perovskite is a promising class of materials for photovoltaic applications and light emitting diodes. However, so far commercialization is still impeded by several drawbacks. Atomic-scale effects have been suggested to be possible causes, but an unequivocal experimental view at the atomic level is missing. Here, we present a low-temperature scanning tunneling microscopy study of single crystal methylammonium lead bromide CH<SUB>3</SUB>NH<SUB>3</SUB>PbBr<SUB>3</SUB>. Topographic images of the in situ cleaved perovskite surface reveal the real-space atomic structure. Compared to the bulk we observe modified arrangements of atoms and molecules on the surface. With the support of density functional theory we explain these by surface reconstruction and a substantial interplay of the orientation of the polar organic cations (CH<SUB>3</SUB>NH<SUB>3</SUB>)<SUP>+</SUP> with the position of the hosting anions. This leads to structurally and electronically distinct domains with ferroelectric and antiferroelectric character. We further demonstrate local probing of defects, which may also impact device performance.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2015/jacsat.2015.137.issue-51/jacs.5b08227/production/images/medium/ja-2015-08227g_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja5b08227'>ACS Electronic Supporting Info</A></P>