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Yunxuan Wang,Tieying Dong,Qijia Xuan,Hong Zhao,Ling Qin,Qingyuan Zhang 한국유방암학회 2018 Journal of breast cancer Vol.21 No.2
Purpose: In this study, we aimed to evaluate lymphocyte-activation gene-3 (LAG-3) expression and its prognostic value in neoadjuvant- treated triple-negative breast cancer (TNBC). Methods: LAG-3, programmed death-1 (PD-1), programmed death ligand- 1 (PD-L1), and CD8+ tumor-infiltrating lymphocyte (TILs) levels were examined using immunohistochemistry in 148 preand 114 post-neoadjuvant chemotherapy (NACT) specimens of human TNBC tissue. Correlations between expression levels and clinicopathological features were analyzed. Prognostic values for combined detection in TNBC following NACT were evaluated. Results: In pre-NACT specimens, LAG-3 expression showed a significant association with pathological complete response (pCR, p=0.038) and was correlated with PD-1 (p<0.001) and PD-L1 (p=0.008). In post-NACT specimens, high expression of LAG-3 showed significant effects on nodal status (p=0.023) and PD-1 (p<0.001). The expression of immune markers on TILs significantly increased following NACT. Multivariate analysis indicated that only nodal status (odds ratio [OR], 0.226; 95% confidence interval [CI], 0.079–0.644; p=0.005) and high quantities of CD8+TILs (OR, 3.186; 95% CI, 1.314–7.721; p=0.010) are independent predictors of pCR. Nodal status (hazard ratio [HR], 2.666; 95% CI, 1.271–5.594; p=0.010), CD8+TILs (HR, 0.313; 95% CI, 0.139–0.705; p=0.005), and the LAG-3- high/PD-L1-high group (HR, 2.829; 95% CI, 1.050–7.623; p=0.040) provided prognostic values for patients with TNBC following NACT. Conclusion: CD8+TILs were sensitive predictive markers in response to NACT. High expression of LAG-3 in residual tissues, especially in combination with PD-L1, was associated with poor prognosis.
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NOVEL HIERARCHICAL NANORODS OF SILICON-DOPED Bi2O2CO3 AND ITS PHOTOCATALYTIC ACTIVITY
Peng Sun,MINDONG CHEN,YUNXUAN ZHAO,JUAN XU,WENQING YAO,YONGFA ZHU,FEI TENG,YUJIAN JIN 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.8
The silicon-doped Bi2O2CO3 nanorods with the interesting hierarchical structure are synthesized by a simple hydrothermal method. The samples are characterized by XRD, X-ray photoelectron spectroscopy (XPS), scanning electron microscope (SEM), high-resolution transmission electron microscopy (HRTEM), Ultraviolet-visible diffuse refectance spectra (UV-DRS) and nitrogen sorption isotherms. It is found that with the increase of silicon content, the XRD peak of the sample significantly shifts toward a low diffraction angle and the particle morphologies change from nanosheets, nanoflowers to hierarchical nanorods. Moreover, the silicon-doped Bi2O2CO3 hierarchical nanorods exhibit improved photocatalytic degradation activities for different types of dyes under simulated solar light irradiation. The improved activity has been mainly attributed to the unique hierarchical nanorods structure and the formation of Si–O–Bi bonds.
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