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      • A Robust Control Methodology based on Active Disturbance Rejection Control and Input Shaping

        Qingru Cui,Yali Xue,Donghai Li,Li Sun 제어로봇시스템학회 2018 제어로봇시스템학회 국제학술대회 논문집 Vol.2018 No.10

        Active disturbance Rejection Control (ADRC) is widely used in a variety of fields during past 20 years. The core component, Extended State Observer (ESO), is designed to estimate the total disturbance and perturbation as well as the system states which are not unmeasurable. The total disturbances are lumped and then compensated in the control law in real time. Thereby the algorithm is independent on the exact model and precise information of plant. To further enhance its performance, input-shaping (IS), as a vibration suppression feed forward method, is used to reduce the overshoot. The simulation results demonstrate that the improved ADRC has a fast response capability and maintains a considerable response of disturbance rejection. It is concluded that the combination of the two techniques are applicable in the cases where the fast disturbance rejection and non-overshoot set-point tracking is favored without a precise model at hand.

      • KCI등재

        Molecular and phylogenetic analysis of Anaplasma spp. in sheep and goats from six provinces of China

        Yan Zhang,Yali Lv,Feifei Zhang,Wenjing Zhang,Jinhong Wang,Yanyan Cui,Rongjun Wang,Fuchun Jian,Longxian Zhang,Changshen Ning 대한수의학회 2016 Journal of Veterinary Science Vol.17 No.4

        Members of the genus Anaplasma are important emerging tick-borne pathogens in both humans and animals in tropical and subtropical areas. Here, we investigated the presence of Anaplasma spp. in 621 sheep and 710 goats from six provinces of China. Polymerase chain reaction(PCR) and DNA sequencing were conducted to determine the prevalence of Anaplasma (A.) phagocytophilum, A. ovis and A. bovis targetingthe 16S ribosomal RNA or the major surface protein 4 gene. PCR revealed Anaplasma in 39.0% (240/621) of sheep and 45.5% (323/710)of goats. The most frequently detected species was A. ovis (88/621, 14.2% for sheep; 129/710, 18.2% for goats), followed by A. bovis (60/621,9.7% for sheep; 74/710, 10.4% for goats) and A. phagocytophilum (33/621, 5.3% for sheep; 15/710, 2.1% for goats). Additionally, eight sheepand 20 goats were found to be infected with three pathogens simultaneously. DNA sequencing confirmed the presence of these three Anaplasmaspecies in the investigated areas, and phylogenetic analysis indicated that there was geographic segregation to a certain extent, as well as arelationship between the host and cluster of A. ovis. The results of the present study provide valuable data that helps understand theepidemiology of anaplasmosis in ruminants from China.

      • KCI등재후보

        SURFACE MODIFICATION AND CHARACTERIZATION OF Fe_3O_4/Au COMPOSITE NANOPARTICLES

        FENG SHI,WENLI HUI,YALI CUI,CHAO CHEN 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2011 NANO Vol.6 No.2

        Fe_3O_4/Au composite nanoparticles were modified with α-thio-ω-carboxy poly (ethylene glycol). Results from XRD, selected area diffraction, high-resolution TEM images, and dynamic lighting scattering illustrate that the particles have a core/shell composite structure and were monodispersed. Surface plasmon resonance measured by UV–Vis indicates that the absorption peak of the modified composite particle characteristic at 532 nm can be stably suspended in a different buffer. The modified composite particles also have good response to external magnetic field. The Fe_3O_4/Au composite nanoparticles are magnetically and optically active, and are useful for simultaneous magnetic and optical detection. Coupled with biomolecules, the advantages of these composite particles make them very promising for biomedical applications in the near future.

      • Human Telomerase Gene and High-Risk Human Papillomavirus Infection are Related to Cervical Intraepithelial Neoplasia

        Zhao, Xu-Ye,Cui, Yongm,Jiang, Shu-Fang,Liu, Ke-Jun,Han, Hai-Qiong,Liu, Xiao-Su,Li, Yali Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2

        Our aims were to evaluate the clinical performance of human telomerase RNA gene component (hTERC gene) amplification assay with high-risk human papillomavirus (HR-HPV) DNA test of Hybrid Capture 2 DNA test (HC2), for the detection of high grade cervical precancerous lesions and cancer (CIN 2+). In addition, the association shown between hTERC gene amplification and HPV DNA test positive in women with and without cervical neoplasia was assessed. There were 92 women who underwent cytology, HR-HPV DNA test, hTERC gene amplification test, colposcopy and biopsy. We compared the clinical performance of hTERC gene test along with HR-HPV DNA test of women with colposcopy and routine screening. The samples were histology-confirmed high-grade cervical intraepithelial neoplasia (CIN 2) or worse (CIN2+) as the positive criterion. The test of hTERC gene showed the hTERC gene amplification positivity increased with the severity of histological abnormality and cytological abnormality. The test of hTERC gene showed higher specificity than HR-HPV DNA test for high-grade lesions (84.4% versus 50%) and also higher positive predictive value (90.4% versus 76.5%). Our results predicted that hTERC gene amplification demonstrated more specific performance for predicting the risk of progression and offer a strong potential as a tool for triage in cervical cancer screening, with the limited sensitive as HR-HPV DNA test.

      • KCI등재

        Genomic diversity of the Avian leukosis virus subgroup J gp85 gene in different organs of an infected chicken

        Fanfeng Meng,Xue Li,Jian Fang,Yalong Gao,Lilong Zhu,Guiju Xing,Fu Tian,Yali Gao,Xuan Dong,Shuang Chang,Peng Zhao,Zhizhong Cui,Zhihao Liu 대한수의학회 2016 Journal of Veterinary Science Vol.17 No.4

        The genomic diversity of Avian leukosis virus subgroup J (ALV-J) was investigated in an experimentally infected chicken. ALV-J variantsin tissues from four different organs of the same bird were re-isolated in DF-1 cells, and their gp85 gene was amplified and cloned. Ten clonesfrom each organ were sequenced and compared with the original inoculum strain, NX0101. The minimum homology of each organ rangedfrom 96.7 to 97.6%, and the lowest homology between organs was only 94.9%, which was much lower than the 99.1% homology of inoculumNX0101, indicating high diversity of ALV-J, even within the same bird. The gp85 mutations from the left kidney, which contained tumors,and the right kidney, which was tumor-free, had higher non-synonymous to synonymous mutation ratios than those in the tumor-bearing liverand lungs. Additionally, the mutational sites of gp85 gene in the kidney were similar, and they differed from those in the liver and lung, implyingthat organ- or tissue-specific selective pressure had a greater influence on the evolution of ALV-J diversity. These results suggest that moreALV-J clones from different organs and tissues should be sequenced and compared to better understand viral evolution and molecularepidemiology in the field.

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