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RISS 인기검색어
- 검색키워드
- 저자 : Xitong Zhang (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Association between Histone Deacetylase 9 Gene Polymorphism and Stroke in Chinese Han Population
Yang, Xitong,Xu, Hongyang,Liu, Dan,Ma, Rong,Zhang, Yuanyuan,Wang, Guangming The Korean Neurosurgical Society 2021 Journal of Korean neurosurgical society Vol.64 No.2
Objective : To explore the correlation between the polymorphism of histone deacetylase 9 gene (rs1060499865, rs723296, rs957960) and ischemic stroke (IS) in Chinese Han population in Dali region. Methods : This study included 155 IS patients and 128 healthy physical examinees. TaqMan-polymerase chain reaction technology and multivariate logistic regression were performed. Results : In the case group, there was no polymorphism of rs1060499865 observed in the two groups; whereas on the rs723296 locus the frequencies of C allele and TC genotype were significantly higher than that in the control group, alleles C and T were associated with a 2.158-fold increase in IS risk, and genotypes TC and TT were associated with a 2.269-fold increase in IS risk. The locus rs957960 exhibited no significant difference between the two groups. Conclusion : An association between rs723296 and the risk of IS was found in the Chinese Han population in Dali region. No significant association was found between rs1060499865, rs957960 and IS in the Chinese Han population in Dali region.
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Yang, Xitong,Ma, Rong,Zhang, Yuanyuan,Wang, Guangming The Korean Neurosurgical Society 2020 Journal of Korean neurosurgical society Vol.63 No.5
To perform a systematic review of the data collected from case-control studies conducted earlier to investigate the correlation between E-selectin S128R polymorphism and ischemic stroke (IS) risk among the Chinese population. The PubMed, Web of Science, Chinese biomedical literature database (CBM), Chinese databases China National Knowledge Infrastructure (CNKI), WanfangData knowledge service platform (Wanfang Data), and information resource integration service platform (VIP) Databases were searched to retrieve case-control studies on the correlation between E-selectin gene S128R polymorphism and IS from the inception of the database till June 2019. The literature was screened, data were extracted, the risk of bias was reviewed, and the studies included were assessed independently by two reviewers. Stata ver. 12.0 software (Stata Corp LLC, College Station, TX, USA) was used to perform the meta-analysis. A total of 2907 cases from eight case-control studies involving 1478 IS patients and 1429 controls were included in this study. The R allele and RS genotype in E-selectin were found to be associated with the risk of IS as per the results of the meta-analysis (R vs. S : odds ratio [OR], 2.75; 95% confidence interval [CI], 2.15-3.51; p<0.00001; RS vs. SS : OR, 2.50; 95% CI, 1.95-3.19; p<0.00001; RR+RS vs. SS : OR, 2.85, 95% CI, 2.21-3.67; p<0.00001). The E-selectin gene S128R polymorphism is likely related to IS based on the results of a meta-analysis in the Chinese population, and the R allele and RS genotype of E-selectin may be IS risk factors.
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A bidirectional valveless piezoelectric micropump with three chambers applying synthetic jet
Xiuhua He,Liang Xu,Xitong Zhang,Song Yang 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.9
A new type of valveless piezoelectric micropump is presented. Synthetic jet and Coanda effect are utilized to achieve larger and bidirectional flow rate. The numerical simulation applying the velocity and pressure boundary conditions as well as the SST turbulence model were utilized to research the performance and internal flow state of the micropump. The simulation method was tested by the previous experimental data and the results matched well. The results suggest that the flow rate of the micropump is related to the Reynolds number and frequency. The entrainment flow rate of synthetic jet accounts for over 80% of the total outflow rate. The outflow rate is much larger than the volume change of the micropump chambers. There is an optimal frequency to obtain the maximum flow rate regarding the volume change of the chambers as a constant. The fluctuation of the flow rate decreases with the increase of frequency. When the frequency is higher than 25 Hz, the outflow can be continuous. Working at the Reynolds number of 1000 and optimal frequency of 50 Hz, the flow rate is 6.8 ml/min.
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