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RISS 인기검색어
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- 저자 : Xinwei Jiang (검색결과 4 건)
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Poisoning effect of CaO on CeO2/TiO2 catalysts for selective catalytic reduction of NO with NH3
Ye Jiang,Xuechong Wang,Changzhong Bao,Shanbo Huang,Xiuxia Zhang,Xinwei Wang 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.6
The effect of CaO on CeO2/TiO2 catalysts prepared by a single step sol-gel method for selective catalytic reduction of NO with NH3 was investigated. The results showed that CaO could severely deactivate the CeO2/TiO2 catalysts. Based on the characterization results obtained by BET, XRD, XPS, H2-TPR and NH3-TPD, the deactivation by CaO of CeO2/TiO2 catalysts should be attributed to pore blockage, lower concentration of Ce on catalyst surface, reduction of Ce3+ and surface adsorbed oxygen, degradation of redox ability and decrease in NH3 adsorption capacity. The theoretical DFT results demonstrated that Ca atom could strongly interact with cerium oxygen, which inhibits the formation and hydrogenation of oxygen vacancies on catalyst surface.
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Xing Xu,Xinwei Jiang,Ju Xie,Feng Wang,Minglei Li 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.4
The trajectory planning plays an important role in realizing the autonomous driving process. The trajectory that reflects the driving habits of human drivers and conforms with people’s driving intuition enables a vehicle to operate smoother and more comfortable when passing through corners, which could improve the acceptability of autonomous vehicles in the market in the future. The research of this paper focuses on planning a human driving characterised trajectory along a road based on the test track that could reflect natural driving behaviour in corners considering the sense of natural and comfortable for the occupants. Firstly, the data collected of the test track are processed and the coordinate system transformation is completed, and the human tested trajectories in the test track is extracted and analysed. Then, the human driving characterised trajectory planning is completed based on optimal control in a lane section on the test track. The trajectory tracking control algorithm based on LQR is designed, and a CarSim/Simulink co-simulation platform is established to track the optimal trajectory generated in a lane and the lane centreline trajectory to verify the superiority of the planned trajectory. The results show that compared with the centreline trajectory, the human driving characterised trajectory planned enables the autonomous vehicle operates smoother and more comfortable, and reflects the characteristic of human drivers to a large extent.
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KETCH1 imports HYL1 to nucleus for miRNA biogenesis in <i>Arabidopsis</i>
Zhang, Zhonghui,Guo, Xinwei,Ge, Chunxiao,Ma, Zeyang,Jiang, Mengqiu,Li, Tianhong,Koiwa, Hisashi,Yang, Seong Wook,Zhang, Xiuren National Academy of Sciences 2017 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.114 No.15
<P>MicroRNA (miRNA) is processed from primary transcripts with hairpin structures (pri-miRNAs) by microprocessors in the nucleus. How cytoplasmic-borne microprocessor components are transported into the nucleus to fulfill their functions remains poorly understood. Here, we report KETCH1 (karyopherin enabling the transport of the cytoplasmic HYL1) as a partner of hyponastic leaves 1 (HYL1) protein, a core component of microprocessor in Arabidopsis and functional counterpart of DGCR8/Pasha in animals. Null mutation of ketch1 is embryonic-lethal, whereas knockdown mutation of ketch1 caused morphological defects, reminiscent of mutants in the miRNA pathway. ketch1 knockdown mutation also substantially reduced miRNA accumulation, but did not alter nuclear-cytoplasmic shuttling of miRNAs. Rather, the mutation significantly reduced nuclear portion of HYL1 protein and correspondingly compromised the pri-miRNA processing in the nucleus. We propose that KETCH1 transports HYL1 from the cytoplasm to the nucleus to constitute functional microprocessor in Arabidopsis. This study provides insight into the largely unknown nuclear-cytoplasmic trafficking process of miRNA biogenesis components through eukaryotes.</P>
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Ruijie Qian,Yawen Guo,Ruihua Wang,Shuai Wang,Xuemei Gao,Ziyang Zhu,Kun Wang,Ke Zhu,Baosong Jiang,Yijian Chen,Zhiyu Wang,Jianzhuang Ren,Xuhua Duan,Xinwei Han 한국생체재료학회 2024 생체재료학회지 Vol.28 No.00
Immunotherapy shows great therapeutic potential for long-term protection against tumor relapse and metastasis. Innate immune sensors, such as cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING), dissolve DNA and induce type I interferon. Through activation of the cGAS/STING pathway, chemotherapy drugs and reversine (REV) may provide synergetic anti-tumor effects. Here, we prepared drug-loaded cell membrane hybrid lipid nanovesicles (LEVs) (designated LEV@DOX@REV) by fusion of cell membranes, phospholipids, doxorubicin (DOX), and REV, to realize accurate delivery to tumors and chemo-immunotherapy. The cell membranes of LEVs confer “homing” abilities. DOX can induce immunogenic cell death as a result of its specific immunomodulatory effects, which promotes the maturation of immune cells and improves the microenvironment of the immune system. REV is proven to efficiently activate cGAS/STING signaling, thereby enhancing the immune system. The antitumor efficacy of LEV@DOX@REV was evaluated in a 4T1 subcutaneous tumor xenograft model, a distant metastatic tumor model, and a liver metastatic tumor model. LEV@DOX@REV facilitated the infiltration of cytotoxic T lymphocytes within tumors, increased the secretion of proinflammatory cytokines, and modified the tumor microenvironment. In conclusion, LEV@DOX@REV displayed favorable antitumor effects and extended the survival of tumor-bearing mice. We therefore successfully developed nanoparticles capable of enhancing immune activation that have potential therapeutic applications for cancer immunotherapy.
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