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Effects of sleep deprivation on coronary heart disease
Ran Wei,Xiaoye Duan,Lixin Guo 대한약리학회 2022 The Korean Journal of Physiology & Pharmacology Vol.26 No.5
The presence of artificial light enables humans to be active 24 h a day. Many people across the globe live in a social culture that encourages staying up late to meet the demands of various activities, such as work and school. Sleep deprivation (SD) is a severe health problem in modern society. Meanwhile, as with cardiometabolic disease, there was an obvious tendency that coronary heart disease (CHD) to become a global epidemic chronic disease. Specifically, SD can significantly increase the morbidity and mortality of CHD. However, the underlying mechanisms responsible for the effects of SD on CHD are multilayered and complex. Inflammatory response, lipid metabolism, oxidative stress, and endothelial function all contribute to cardiovascular lesions. In this review, the effects of SD on CHD development are summarized, and SD-related pathogenesis of coronary artery lesions is discussed. In general, early assessment of SD played a vital role in preventing the harmful consequences of CHD. INTRODUCTION Many individuals globally live in a social culture that encourages staying up late to meet the demands of various activities, such as work and school. The causes of poor sleep hygiene can include alcohol use, stimulant intake (including caffeine), and excessive Internet usage, as well as disease states, such as sleep apnea, which prevent individuals from acquiring adequate sleep duration and quality [1-8]. At the same time, shift work (e.g., night shifts) can change workers' sleep patterns, leading to emotional impulsiveness, reduced cognitive ability, diminished processing efficiency, and impaired executive function [9-15]. Further, shift workers have been shown to be at greater risk for the development of metabolic disorders and cardiovascular disease (CVD) [16-23]. Sleep deprivation (SD) has become a severe health problem in modern society. While adults require between seven and nine hours of sleep per night, more than a third sleep less than six [24]. The
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