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RISS 인기검색어
- 검색키워드
- 저자 : Xiaowen Fan (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
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Fan, Xiaowen,Peng, Ying,Yang, Xingang,Wang, Chao,Pan, Weisan,Nie, Shufang 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.8
The purpose of this study was to evaluate complexes of vinpocetine (VIN), a poorly water-soluble base type drug, with $Hydroxypropyl-{\beta}-cyclodextrin$ ($HP-{\beta}-CD$) in aqueous environment and in solid state, with or without citric acid (CA) as an acidifier of the complexation medium. The apparent stability constant ($K_c$) calculated by phase solubility was 282 $M^{-1}$ and the complexation in solution was structurally characterized by $^1H-NMR$ which showed VIN was likely to fit into the cyclodextrin cavity with its phenyl ring and ethyl ester bond. Solid complexes of VIN and $HP-{\beta}-CD$ were prepared by kneading (KE), co-evaporating (CE) and freeze-drying (FD) methods. Physical mixtures were prepared for comparison. The study in the solid state included the differential scanning calorimetry (DSC), X-ray diffractometry (XRD) and infrared absorption spectroscopy (IR). From these analyses, CE and FD products were found in amorphous state, allowing to the conclusion of strong evidences of inclusion complex formation However, the dissolution test showed that only $VIN/HP-{\beta}-CD+CA$ complexes by CE and FD method could provide satisfying dissolution behavior (rapid, complete and lasting) when compared to that of $VIN/HP-{\beta}-CD$ complexes. Interestingly, the addition of CA in inclusion complexes could significantly decrease the amount of $HP-{\beta}-CD$ needed to solubilize the same amount of VIN and thereby reducing the formulation bulk. Furthermore, in-vivo study revealed that the bioavailability of VIN after oral administration to rabbits (n=6) was significantly improved by $VIN/HP-{\beta}-CD+CA$ inclusion complex.
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A new electromagnetic micromixer for the mixing of two electrolyte solutions
Yiping Chen,Xiaowen Fan,김창녕 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.12
A novel magneto-hydrodynamic (MHD) micro-mixer is proposed in this current study, and performed is the numerical analysis of the mixing features of two different electrolyte solutions in this device with the uniformly applied magnetic field. This fluidic device is designed in a minimized size, with mixing and pumping functions. In this device, there exist two or three curved-walled regions responsible for mixing or pumping, and three or four rectangular ducts for the inflow-, middle-, and outflow-channels. The current, induced from two different electrodes applying different electric potentials, is coupled with the applied magnetic field, yielding Lorentz force to propel the two solutions to mix. Within the mixer, the fluid is directed to flow along the curved surface in the curved-walled regions, and to move forward to the outlet. CFX code is utilized to analyze the flow characteristics. This study investigates the mixing efficiency in diverse cases with different voltages of the electrodes and with different geometries of the mixing region. The results testify that the novel mixer shows higher mixing performance when higher input voltages (absolute value) are applied to the electrodes of the mixing region, when the input voltages (absolute value) applied to the electrodes of the pumping region is lower, and when more mixing regions are adopted.
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Yang Luo,Xiaowen Fan,Chang Nyung Kim 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.10
Three dimensional magnetohydrodynamic (MHD) flows in a U-channel formed by inlet-, connecting- and outlet-channel are numerically examined with CFX code in the current research. The impacts of the flow velocities, the Hartmann numbers, the spatially changing channel-wall electric conductivity and of the magnetic field orientation on the MHD flow features are studied. Here, considered are the situations where the inlet-channel-wall electric conductivity is changed, while the connecting- and outlet-channel-wall electric conductivity is fixed. Velocity, pressure drop, current density and electric potential are analyzed in the present study. The highest value of velocity is observed in the right-angle segments. Typical “M-type” velocity profiles can be obtained only when the magnetic field and the main flow plane are transverse to each other, while the “M-type” velocity profile may not obtained when the magnetic field intensity is very low. The pressure drop decreases when the inlet channel-wall electric conductivity decreases, and it also decreases with the decreasing of the flow velocity and of the Hartmann number. When the magnetic field is parallel to main flow, the lowest pressure drop can be observed as the channel-wall electric conductivity of the inlet channel is the lowest. With the lower pressure drop, the mechanical stress of the duct can be minimized.
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In Vitro and In Vivo Studies on the Complexes of Vinpocetine with Hydroxypropyl-β-cyclodextrin
Shufang Nie,Xiaowen Fan,Ying Peng,Xingang Yang,Chao Wang,Weisan Pan 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.8
The purpose of this study was to evaluate complexes of vinpocetine (VIN), a poorly water-soluble base type drug, with hydroxypropyl-β-cyclodextrin (HP-β-CD) in aqueous environment and in solid state, with or without citric acid (CA) as an acidifier of the complexation medium. The apparent stability constant (Kc) calculated by phase solubility was 282 M-1 and the complexation in solution was structurally characterized by 1H-NMR which showed VIN was likely to fit into the cyclodextrin cavity with its phenyl ring and ethyl ester bond. Solid complexes of VIN and HP-β-CD were prepared by kneading (KE), co-evaporating (CE) and freeze-drying (FD) methods. Physical mixtures were prepared for comparison. The study in the solid state included the differential scanning calorimetry (DSC), X-ray diffractometry (XRD) and infrared absorption spectroscopy (IR). From these analyses, CE and FD products were found in amorphous state, allowing to the conclusion of strong evidences of inclusion complex formation. However, the dissolution test showed that only VIN/HP-β-CD+CA complexes by CE and FD method could provide satisfying dissolution behavior (rapid, complete and lasting) when compared to that of VIN/HP-β-CD complexes. Interestingly, the addition of CA in inclusion complexes could significantly decrease the amount of HP-β-CD needed to solubilize the same amount of VIN and thereby reducing the formulation bulk. Furthermore, in-vivo study revealed that the bioavailability of VIN after oral administration to rabbits (n=6) was significantly improved by VIN/HP-β-CD+CA inclusion complex.
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