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Xiaoli Xie,Haolin Su,Mulin Pang 한국강구조학회 2023 International Journal of Steel Structures Vol.23 No.3
With the span of steel truss girder cable-stayed bridge (STGCB) increases, it is easy to have local stability problems caused by the increase of axial forces, and the whole steel truss girder uses a large amount of steel. To solve these problems, a new laminated girder single tower cable-stayed bridge (NLGCB) is proposed in this paper. The structure of NLGCB is similar to STGCB, the difference is that the lower chords of the main girder near the cable tower are changed into the concrete structure, while the web members and upper chords are made of steel. Thus, a new type of concrete-steel laminated girder is formed, so as to improve the stress characteristics of the main girder. In order to verify the superiority of mechanical properties of NLGCB, a test bridge with an unequal span (5 m + 6 m) was constructed. The natural frequency of the first in-plane vibration of the bridge was measured by the pulsation test, and the stresses and deflections of the structure were tested by the static load test. The static and dynamic characteristics of a 300 m + 300 m span bridge were analyzed by finite element software and compared with STGCB. The results show that the natural frequency of the first in-plane vibration of the structure is close to the calculated value, and the vibration modes are consistent with the finite element simulation ones. When the steel consumption is reduced by 13.7% and the concrete consumption is not much, the strength, stiffness, natural vibration frequency, and stability of the structure are greatly improved.
Disruption of Striated Preferentially Expressed Gene Locus Leads to Dilated Cardiomyopathy in Mice
Liu, Xiaoli,Ramjiganesh, Tripurasundari,Chen, Yen-Hsu,Chung, Su Wol,Hall, Sean R.,Schissel, Scott L.,Padera Jr, Robert F.,Liao, Ronglih,Ackerman, Kate G.,Kajstura, Jan,Leri, Annarosa,Anversa, Piero,Ye Ovid Technologies Wolters Kluwer -American Heart A 2009 CIRCULATION - Vol.119 No.2
<P>BACKGROUND: The striated preferentially expressed gene (Speg) generates 4 different isoforms through alternative promoter use and tissue-specific splicing. Depending on the cell type, Speg isoforms may serve as markers of striated or smooth muscle differentiation. METHODS AND RESULTS: To elucidate function of Speg gene isoforms, we disrupted the Speg gene locus in mice by replacing common exons 8, 9, and 10 with a lacZ gene. beta-Galactosidase activity was detected in cardiomyocytes of the developing heart starting at day 11.5 days post coitum (dpc). beta-Galactosidase activity in other cell types, including vascular smooth muscle cells, did not begin until 18.5 dpc. In the developing heart, protein expression of only Spegalpha and Spegbeta isoforms was present in cardiomyocytes. Homozygous Speg mutant hearts began to enlarge by 16.5 dpc, and by 18.5 dpc, they demonstrated dilation of right and left atria and ventricles. These cardiac abnormalities in the absence of Speg were associated with a cellular hypertrophic response, myofibril degeneration, and a marked decrease in cardiac function. Moreover, Speg mutant mice exhibited significant neonatal mortality, with increased death occurring by 2 days after birth. CONCLUSIONS: These findings demonstrate that mutation of the Speg locus leads to cardiac dysfunction and a phenotype consistent with a dilated cardiomyopathy.</P>
Zhengmin Yu,Xiaoli Su,Denghu Wei,Shu-Juan Yao,Huiyan Ma,Hui Zhao,Xipeng Pu,Wenzhi Li,Jie Wang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.4
3D structure composite made of tiny basic nickel carbonate arrays on the surface of reduced graphene oxide nanosheets (G-NiCH) are prepared by the hydrothermal method. The specific surface area of the G-NiCH composites is twice that of single basic nickel carbonate, which is due to the tiny basic nickel carbonate arrays structure wherein each individual nanoneedle is about 20 nm in length and 2 nm in width. The G-NiCH electrodes display high-efficiency electrochemical performance with good specific capacitance (1230 F g -1) and excellent stability (100% capacitance retention after 2000 cycles). This is attributed to the synergistic effect that reduced graphene oxide offer fast electron transmission path and basic nickel carbonate act as high effective active material.
Elk-3 is a KLF4-regulated gene that modulates the phagocytosis of bacteria by macrophages
Tsoyi, Konstantin,Geldart, Adriana M.,Christou, Helen,Liu, Xiaoli,Chung, Su Wol,Perrella, Mark A. Federation of American Societies for Experimental 2015 Journal of Leukocyte Biology Vol.97 No.1
<P>Down-regulation of Elk-3 by bacterial LPS, in part through the transcriptional repressor KLF4, allows for up-regulation of HO-1 and a compensatory phagocytic response in macrophages.</P><P>ETS family proteins play a role in immune responses. A unique member of this family, Elk-3, is a transcriptional repressor that regulates the expression of HO-1. Elk-3 is very sensitive to the effects of inflammatory mediators and is down-regulated by bacterial endotoxin (LPS). In the present study, exposure of mouse macrophages to <I>Escherichia coli</I> LPS resulted in decreased, full-length, and splice-variant isoforms of Elk-3. We isolated the Elk-3 promoter and demonstrated that LPS also decreased promoter activity. The Elk-3 promoter contains GC-rich regions that are putative binding sites for zinc-finger transcription factors, such as Sp1 and KLFs. Mutation of the GC-rich region from bp –613 to –603 blunted LPS-induced down-regulation of the Elk-3 promoter. Similar to the LPS response, coexpression of KLF4 led to repression of Elk-3 promoter activity, whereas coexpression of Sp1 increased activity. ChIP assays revealed that KLF4 binding to the Elk-3 promoter was increased by LPS exposure, and Sp1 binding was decreased. Thus, down-regulation of Elk-3 by bacterial LPS is regulated, in part, by the transcriptional repressor KLF4. Overexpression of Elk-3, in the presence of <I>E. coli</I> bacteria, resulted in decreased macrophage phagocytosis. To determine whether limited expression of HO-1 may contribute to this response, we exposed HO-1-deficient bone marrow-derived macrophages to <I>E. coli</I> and found a comparable reduction in bacterial phagocytosis. These data suggest that down-regulation of Elk-3 and the subsequent induction of HO-1 are important for macrophage function during the inflammatory response to infection.</P>