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MiR-186 Inhibited Migration of NSCLC via Targeting cdc42 and Effecting EMT Process
Dong, Ying,Jin, Xintian,Sun, Zhiqiang,Zhao, Yueming,Song, Xianjing Korean Society for Molecular and Cellular Biology 2017 Molecules and cells Vol.40 No.3
In this study, qRT-PCR was employed to identify that miR-186 expression level in NSCLC tissues are highly associated with lymph node metastasis. In addition, through the application of western blotting, luciferase assay and qRT-PCR, it was found that miR-186 targeted 3'UTR of cdc42 mRNA and down-regulated cdc42 protein level in a post-transcriptional manner. Transwell assay indicated that cdc42 partially reversed the effect of miR-186 mimics. Besides, miR-186 was proved to regulate EMT by influencing biomarkers of this process and cell adhesion ability. Thus, miR-186 is a potential target for NSCLC therapy. miR-186 is proposed to be one of tumor-suppressors and may serve as a therapeutic target in NSCLC treatment.
MiR-186 Inhibited Migration of NSCLC via Targeting cdc42 and Effecting EMT Process
Ying Dong,Xintian Jin,Zhiqiang Sun,Yueming Zhao,Xianjing Song 한국분자세포생물학회 2017 Molecules and cells Vol.40 No.3
In this study, qRT-PCR was employed to identify that miR-186 expression level in NSCLC tissues are highly associated with lymph node metastasis. In addition, through the application of western blotting, luciferase assay and qRT-PCR, it was found that miR-186 targeted 3UTR of cdc42 mRNA and down-regulated cdc42 protein level in a post-transcriptional manner. Transwell assay indicated that cdc42 partially reversed the effect of miR-186 mimics. Besides, miR-186 was proved to regulate EMT by influencing biomarkers of this process and cell adhesion ability. Thus, miR-186 is a potential target for NSCLC therapy. miR-186 is proposed to be one of tumor-suppressors and may serve as a therapeutic target in NSCLC treatment.