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      • Distraction Osteogenesis of Free Interpositional Membranous Bone : Experimental Design

        Cho, Byung Chae,Lee, Jung Hyung,Baik, Bong Soo,Wein Liou, Eric Jein,Figueroa, Alvaro A.,Cohen, Mimis 경북대학교 병원 2001 경북대학교병원의학연구소논문집 Vol.5 No.1

        The propose of this study is to explore the possibility of bone formation in distraction osteogenesis of the free interpositional membranous bone. Three canine dogs were used as subjects.Two mandibular osteotomies were made in the mandibular body,The oral soft tissue and periosteum of the segment between the two osteotomies were freed from preiosteum amd the surrounding soft tissue as a free interpositional bone graft 2 ㎝ wide was created.The free interpositional bone was fixed to the proximal mandibular body with miniplate.The external fixation device was applied to the proximal mandibular body and the distal mandibular body. Mndibular distractions were performed postperatively at a rate of 1㎜/day for a total of 10-㎜ distraction for 10days.The latency period was 1 week in Dog1, 2weeks in Dog2, and 3 weeks in Dog3.Three dogs were killed 6 weeks after distraction, and interpositional bone specimens were obtained.In Dogs1 and 2, the free interpositional bone showed servere resption and had no new bone formation at the distracted area.However, in Dog3, new bone developed along the distracted gap. Our study demonstrated the possibility of distraction osetogenesis in the free interpositional membranous bone and suggested that free interpositional membranous bone be allowed, under rigid fixation device, to have enough revascularization from surrounding tissue to have osteogenesis for at least 3 weeks or even more.

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