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Influence of Corrosion on Anchoring Bond Behavior of Jointed Rock Mass
Wantao Ding,Zhongrong Wang,Xinghang Huang,Lei Chen,Yingjie Zheng 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.4
In order to investigate the effect of corrosion on bond behavior of anchored jointed rock masses, based on the migration law of pitting corrosion obtained by laboratory tests and the concept of strength reduction, the anchoring pull-out test of jointed rock mass was simulated by using Discrete Element Method (DEM). The results show that for uncorroded rock specimens, due to the existence of joints, there are significant differences for granular displacement and bond failure on both sides of the rock bolt during pull-out process, and phenomenon of eccentric tension also appears; for corroded rock specimens, the reduction rate of bond strength and slip ratio of single and double joint specimens decrease linearly with the increase of pitting corrosion rate. The decreasing rate gets fast with the increase of joints, but it is not a multiple relationship. Compared with the test with uncorroded specimens, when the pitting corrosion rate is 15%, the maximum pull-out load of the single-joint specimen with joint angel of 45° is reduced by 17.8%, and the slip value is reduced by 14.6%; the maximum pull-out load of the double-joint specimen is reduced by 31.9%, and the slip value is reduced by 24.9%. The numerical test results are in good agreement with the laboratory test results. The research results can provide reference for the selection and optimization of the design parameters of anchoring support structure of jointed rock mass under the erosion environment in the future.
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mRNA nanodelivery systems: Targeting strategies and administration routes
Mujie Yuan,Zeyu Han,Yan Liang,Yong Sun,Bin He,Wantao Chen,Fan Li 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
With the great success of coronavirus disease (COVID-19) messenger ribonucleic acid (mRNA) vaccines, mRNA therapeutics have gained significant momentum for the prevention and treatment of various refractory diseases. To function efficiently in vivo and overcome clinical limitations, mRNA demands safe and stable vectors and a reasonable administration route, bypassing multiple biological barriers and achieving organ-specific targeted delivery of mRNA. Nanoparticle (NP)-based delivery systems representing leading vector approaches ensure the successful intracellular delivery of mRNA to the target organ. In this review, chemical modifications of mRNA and various types of advanced mRNA NPs, including lipid NPs and polymers are summarized. The importance of passive targeting, especially endogenous targeting, and active targeting in mRNA nano-delivery is emphasized, and different cellular endocytic mechanisms are discussed. Most importantly, based on the above content and the physiological structure characteristics of various organs in vivo, the design strategies of mRNA NPs targeting different organs and cells are classified and discussed. Furthermore, the influence of administration routes on targeting design is highlighted. Finally, an outlook on the remaining challenges and future development toward mRNA targeted therapies and precision medicine is provided.
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