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Oh, Wang-Yuhl,Vakoc, Benjamin J.,Shishkov, Milen,Tearney, Guillermo J.,Bouma, Brett E. The Optical Society 2010 Optics letters Vol.35 No.17
<P>We demonstrate a high-speed wavelength-swept laser with a tuning range of 104nm (1228-1332nm) and a repetition rate of 403kHz. The design of the laser utilizes a high-finesse polygon-based wavelength-scanning filter and a short-length unidirectional ring resonator. Optical frequency domain imaging of the human skin in vivo is presented using this laser, and the system shows sensitivity of higher than 98dB with single-side ranging depth of 1.7mm over 4dB sensitivity roll-off.</P>
Oh, Nuri,Kim, Yongjoo,Kweon, Hee-Seok,Oh, Wang-Yuhl,Park, Ji-Ho American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.34
<P>The introduction of nanoparticle-mediated delivery and therapy has revolutionized cancer treatment approaches. However, there has been limited success in clinical trials because current approaches have not simultaneously satisfied therapeutic efficacy and biosafety criteria to an adequate degree. Here, we employ efficient macrophage-mediated exocytosis of elongated nanoparticles to facilitate their localization in tumor cells for cancer therapy and their transport to hepatocytes for hepatobiliary excretion. In vitro studies show that PEGylated high-aspect ratio gold nanoparticles exit macrophages more rapidly and remain in tumor cells longer, compared with low-aspect ratio and spherical nanoparticles. In tumors, high-aspect ratio nanoparticles tend to stay in tumor cells and escape from tumor-associated macrophages when they are taken up by those cells. In the liver, high-aspect ratio nanoparticles cleared by Kupffer cells mostly take the hepatobiliary excretion pathway through efficient Kupffer cell-hepatocyte transfer. Furthermore, we demonstrate that time-dependent localization of elongated gold nanoparticles toward tumor cells in tumor tissues enhances the overall phototherapeutic outcome. Engineering nanoparticles to modulate their exocytosis provides a new approach to improve cancer nanomedicine and pave the way toward clinical translation.</P> [FIG OMISSION]</BR>
Polarization-sensitive OFDI using polarization-multiplexed wavelength-swept laser.
Cho, Han Saem,Oh, Wang-Yuhl Optical Society of America 2014 Optics letters Vol.39 No.14
<P>We demonstrate a novel polarization-sensitive optical frequency domain imaging system employing passive polarization multiplexing. Simple modification of a fiber delay line in the wavelength-swept light source enables illumination with two perpendicular polarizations that are required for determination of the Stokes vector components of the light reflected from each depth of the tissue. This simple all-passive approach provides a robust and low-cost solution for PS imaging replacing relatively complex conventional schemes such as polarization modulation or frequency-encoded polarization multiplexing.</P>
Zhang, Ellen Ziyi,Oh, Wang-Yuhl,Villiger, Martin L,Chen, Liang,Bouma, Brett E,Vakoc, Benjamin J Optical Society of America 2013 Optics express Vol.21 No.1
<P>Polarization mode dispersion (PMD), which can be induced by circulators or even moderate lengths of optical fiber, is known to be a dominant source of instrumentation noise in fiber-based PS-OCT systems. In this paper we propose a novel PMD compensation method that measures system PMD using three fixed calibration signals, numerically corrects for these instrument effects and reconstructs an improved sample image. Using a frequency multiplexed PS-OFDI setup, we validate the proposed method by comparing birefringence noise in images of intralipid, muscle, and tendon with and without PMD compensation.</P>
Development of Dual Beam High Speed Doppler OFDI
SunHee Kim,TaeJin Park,Wang-Yuhl Oh 한국비파괴검사학회 2013 한국비파괴검사학회지 Vol.33 No.3
This paper describes development of a high speed Doppler OFDI system for non-invasive vascular imaging. Doppler OFDI (optical frequency domain imaging) is one of the phase-resolved second generation OCT (optical coherence tomography) techniques for high resolution imaging of moving elements in biological tissues. To achieve a phase-resolved imaging, two temporally separated measurements are required. In a conventional Doppler OCT, a pair of massively oversampled successive A-lines is used to minimize de-correlation noise at the expense of significant imaging speed reduction. To minimize a de-correlation noise between targeted two measurements without suffering from significant imaging speed reduction, several methods have been developed such as an optimized scanning pattern and polarization multiplexed dual beam scanning. This research represent novel imaging technique using frequency multiplexed dual beam illumination to measure exactly same position with aimed time interval. Developed system has been verified using a tissue phantom and mouse vessel imaging.
Development of Dual Beam High Speed Doppler OFDI
Kim, SunHee,Park, TaeJin,Oh, Wang-Yuhl The Korean Society for Nondestructive Testing 2013 한국비파괴검사학회지 Vol.33 No.3
This paper describes development of a high speed Doppler OFDI system for non-invasive vascular imaging. Doppler OFDI (optical frequency domain imaging) is one of the phase-resolved second generation OCT (optical coherence tomography) techniques for high resolution imaging of moving elements in biological tissues. To achieve a phase-resolved imaging, two temporally separated measurements are required. In a conventional Doppler OCT, a pair of massively oversampled successive A-lines is used to minimize de-correlation noise at the expense of significant imaging speed reduction. To minimize a de-correlation noise between targeted two measurements without suffering from significant imaging speed reduction, several methods have been developed such as an optimized scanning pattern and polarization multiplexed dual beam scanning. This research represent novel imaging technique using frequency multiplexed dual beam illumination to measure exactly same position with aimed time interval. Developed system has been verified using a tissue phantom and mouse vessel imaging.
Kim, Tae Shik,Jang, Sun-Joo,Oh, Nuri,Kim, Yongjoo,Park, Taejin,Park, Jiho,Oh, Wang-Yuhl Optical Society of America 2014 Optics letters Vol.39 No.10
<P>We demonstrate a dual-wavelength band optical frequency domain imaging (OFDI) system that provides high-resolution spectroscopic imaging with metallic nanoparticles as exogenous contrast agents. The local increase of the OFDI signal by elastic scattering from two different custom-fabricated nonspherical nanoparticles resonant at each wavelength band of the system was successfully detected, and we were able to distinguish and visualize the location of each of the nanoparticles in a scattering sample and in biological tissue.</P>