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Tongyu Li,Weiwei Shi,Jie Yao,Jingyun Hu,Qiong Sun,Jing Meng,Jian Wan,Haihan Song,Hangxiang Wang 한국생체재료학회 2022 생체재료학회지 Vol.26 No.1
Background: Circular RNAs (circRNAs) have important functions in many fields of cancer biology. In particular, we previously reported that the oncogenic circRNA, circPRMT5, has a major role in bladder cancer progression. Therapy based on circRNAs have good prospects as anticancer strategies. While anti-circRNAs are emerging as therapeutics, the specific in vivo delivery of anti-circRNAs into cancer cells has not been reported and remains challenging. Methods: Synthesized chrysotile nanotubes (SCNTs) with a relatively uniform length (~ 200 nm) have been designed to deliver an siRNA against the oncogenic circPRMT5 (si-circPRMT5) inhibit circPRMT5. In addition, the antitumor effects and safety evaluation of SCNTs/si-circPRMT5 was assessed with a series of in vitro and in vivo assays. Results: The results showed that SCNTs/si-circPRMT5 nanomaterials prolong si-circPRMT5’s half-life in circulation, enhance its specific uptake by tumor cells, and maximize the silencing efficiency of circPRMT5. In vitro, SCNTs encapsulating si-circPRMT5 could inhibit bladder cancer cell growth and progression. In vivo, SCNTs/si-circPRMT5 inhibited growth and metastasis in three bladder tumor models (a subcutaneous model, a tail vein injection lung metastatic model, and an in situ model) without obvious toxicities. Mechanistic study showed that SCNTs/sicircPRMT5 regulated the miR-30c/SNAIL1/E-cadherin axis, inhibiting bladder cancer growth and progression. Conclusion: The results highlight the potential therapeutic utility of SCNTs/si-circPRMT5 to deliver si-circPRMT5 to treat bladder cancer. Keywords: Synthesized chrysotile nanomaterials, Gene therapy, Targeted delivery, CircPRMT5, SiRNA, Bladder cancer
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Zhulin Li,Cuirong Wang,Haiyan Lv,Tongyu Xu 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.9
Hadoop uses a reliable, efficient and scalable way to process data. It provides a good solution for dealing with big data. The task scheduler is the core component of Hadoop, and it is responsible for the managing and allocating the cluster resources. Therefore, scheduling algorithm directly affects the overall performance of Hadoop platform and utilization of cluster resource. Based on this, the improved accelerate particle swarm algorithm (IAPSO) is introduced to the cloud environment, and to solve the cloud task scheduling problem in this article. When we use particle swarm algorithm for task scheduling, the tasks are considered as particles, the resource pool is seen as the search space, and the process of finding the optimal solution is considered as a process of task scheduling. If all the sub tasks find the appropriate resources, then stop the iteration and allocate sub asks to the resource nodes. Finally, we simulate the experiment by using CloudSim software. When a single type of task is committed, our algorithm and the other three algorithms can also be used to complete the task scheduling process, and our algorithm is more efficient. But in practice, the cloud computing environment is facing multiuser, and the types of tasks are also varied. With the increase in the number of tasks, the advantage of the other three algorithms decreases gradually, but algorithm in this paper has been exhibited higher efficiency. In addition, with the increase of the number of nodes, task completed time of the algorithm in this paper is significantly less than the other three algorithms, and it has a steady downward trend. Therefore, IAPSO algorithm which is proposed in this paper is applied to solve task scheduling problem in the cloud environment, and it can effectively improve the efficiency of task scheduling.
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Optimization of a crossbar parallel machine tool based on workspace and dexterity
Fang Xifeng,Zhang Sichong,Xu Qinhuan,Wang Tongyue,Liu Yuanwei,Chen Xiaogang 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.8
Increasing workspace and improving dexterity are important tasks for the design of parallel machine tools. The workspace of a crossbarparallel machine tool with constraints is obtained by using a 3D search method based on inverse kinematics. The new Jacobian matrixof the machine is also derived by using the natural coordinate method. Dexterity distribution of the machine tool is obtained on the basisof the workspace and the new Jacobian matrix. Influences of the structural parameters on the workspace volume index (WVI) and globaldexterity index (GDI) are analyzed. Structural optimization is conducted by treating the WVI and GDI as the global optimization goals. Unlike the initial data, the optimized results increased by 0.43 and 0.34 times.
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Wanli Kang,Menglan Li,Hongbin Yang,Xin Kang,Fang Wang,Haizhuang Jiang,Min Zhang,Tongyu Zhu,Bauyrzhan Sarsenbekuly 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.93 No.-
High-frequency pulsed alternating currentfield (HFPACF) has attracted attentions owing to its excellentperformances of eliminating short circuit, saving energy and reducing environmental pollution. To studythe coalescence mechanism of aqueous drops in water-in-oil (W/O) emulsions under HFPACF, micro-behavior of dispersed drops for W/O emulsion was monitored by using a self-designed micro-visualmodel and coalescence mechanism was analyzed by discussing effects of pulse amplitude, pulsefrequency, pulse width ratio, demulsifier concentration, aqueous mass ratio of emulsion, and differentmodel oil emulsions. The results show that the dispersed drops coalesce under the action of electricfield,and the particle size of dispersed drops increases with the increase of pulse frequency and amplitude. When the pulse frequency or amplitude reach to a critical value, aqueous drops are driven to form waterstring or water channel between two electrodes which hinders further drops coalescence in other areas. However, with the increase of pulse width ratio, the size of dispersed drops increases slowly. Theoptimum pulse frequency and pulse amplitude are obtained at 3.9 kV and 4.21 kHz, respectively, theoptimal pulse width range is 54.9%-84.4%. When the concentration of demulsifier is 60 mg/L, thesynergistic demulsification effect achieves the highest performance. When the aqueous mass ratio ofemulsion reaches a high level (over 30%), which means the drops in emulsion have big size, thecoalescence performance under the same electricfield strength is great. Also, it is discovered that thedispersed drops in Yongping model oil emulsion have difficulty in forming water chains, since there aremuch asphaltenes and resins in the water-oil interface leading to high strength offilm. For Shuanghe oilemulsion drops are prevented from coalescing, because it contains a mass of paraffin, which can stabilizeemulsion at low temperature.
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