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Xi-Peng Sun,Li-Li Wan,Quan-Jun Yang,Yan Huo,Yong-Long Han,Cheng Guo 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.7
The clinical use of doxorubicin (DOX) is limited by its dose-dependent cardiotoxicity. The present study investigated the effects of scutellarin against DOX-induced cardiotoxicity in rats using pharmacodynamic and pharmacokinetic approaches. DOX (20 mg/kg) was injected intraperitoneally (i.p.) as a single dose, and scutellarin (5 mg/kg/day) was injected intravenously (i.v.) for 3 days. Rats treated with DOX showed acute cardiotoxicity as indicated by the elevated serum lactate dehydrogenase (LDH) activity (4057.8 ± 107.2 vs. 2032.7 ± 70.95), tissue malondialdehyde (MDA) level (2.083 ± 0.10 vs. 1.103 ± 0.09), cardiac troponin T (cTnT) concentration (0.1695 ± 0.0114 ng/mL), the decreased left ventricular ejection fraction (LVEF) (47.75 ± 15.79 vs. 78.72 ± 7.25) and left ventricular fractional shortening (LVFS) (20.66 ± 8.06 vs. 43.7 ± 6.76) compared with those of the control group. Cotreatment with scutellarin significantly decreased the LDH activity (2595.9 ± 72.73), MDA level (1.380 ± 0.06), cTnT concentration (0.0222 ± 0.0041 ng/ m L), increased LVEF (76.70 ± 3.91) and LVFS (40.28 ± 3.68). Histopathological studies showed disruption of cardiac tissues in the DOX groups. Cotreatment with scutellarin reduced the damage to cardiac tissues. In the pharmacokinetic and tissue distribution study, scutellarin reduced the heart tissue exposure to DOX but did not change the AUC of plasma. These results suggest that scutellarin can protect against DOX-induced acute cardiotoxicity through its antioxidant activity and alterations of heart concentrations.
Phase Switching Mechanism for WiFi-based Long Distance Networks in Industrial Real-Time Applications
( Jintao Wang ),( Xi Jin ),( Peng Zeng ),( Zhaowei Wang ),( Ming Wan ) 한국인터넷정보학회 2017 KSII Transactions on Internet and Information Syst Vol.11 No.1
High-quality industrial control is critical to ensuring production quality, reducing production costs, improving management levels and stabilizing equipment and long-term operations. WiFi-based Long Distance (WiLD) networks have been used as remote industrial control networks. Real-time performance is essential to industrial control. However, the original mechanism of WiLD networks does not minimize end-to-end delay and restricts improvement of real-time performance. In this paper, we propose two algorithms to obtain the transmitting/receiving phase cycle length for each node such that real time constraints can be satisfied and phase switching overhead can be minimized. The first algorithm is based on the branch and bound method, which identifies an optimal solution. The second is a fast heuristic algorithm. The experimental results show that the execution time of the algorithm based on branch and bound is less than that of the heuristic algorithm when the network is complex and that the performance of the heuristic algorithm is close to the optimal solution.