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Wan Siying,Wu Duo,Niu Gengyun,Liu Ting,Wei Meicai 한국곤충학회 2022 Entomological Research Vol.52 No.1
Arge nipponensis group is proposed for 12 East Asian species. A key to species of this group is provided. Arge aurora Wei, sp. nov., a widespread species in China is described. It has been misidentified as Arge nipponensis Rohwer, 1910 in China since 1927. Arge nipponensis Rohwer is removed from the faunal list of China. The ovipositor and genitalia of A. nipponensis are described and figured for the first time. The geographic distribution analysis indicated that geographical barriers were probably the key to the distribution of A. aurora and A. nipponensis.
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Examining the effect of spatial distribution of disintegrant particles on tablet disintegratability
Zheng Audrey Yi,Huang Wei Wei,Poon Li Ying Jolene,Wong Eunice Siying,Heng Paul Wan Sia,Chan Lai Wah 한국약제학회 2024 Journal of Pharmaceutical Investigation Vol.54 No.2
Purpose Superdisintegrants are typically used at low concentrations in tablets. As a result, the spatial distribution of disintegrant particles within the tablet may be inhomogeneous, resulting in varied disintegration times. This study aimed to investigate the effect of disintegrant spatial distribution on tablet disintegratability. Methods Tablets with various degrees of disintegrant spatial distribution were engineered using a novel experimental design. The effects of relative spatial distribution of disintegrant particles on tablet tensile strength, liquid penetration rate and disintegration time were investigated. Results It was observed that increased clustering of disintegrant particles generally promoted faster tablet disintegration due to more localized swelling and strain recovery of sodium starch glycolate and crospovidone, respectively. However, for tablets with insoluble fillers and sodium starch glycolate, a high degree of disintegrant clustering prolonged disintegration due to the formation of gel plugs which impeded liquid penetration into the tablet and caused the tablet to break up into floccules instead. Tablets made with insoluble fillers were also found to be more sensitive to changes in disintegrant spatial distribution compared to those containing soluble fillers. Conclusion Overall, the effects of disintegrant spatial distribution were dependent on the type of disintegrant and filler used.
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