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- 저자 : Vikas Chander (검색결과 2 건)
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Antioxidants in the Prevention of Renal Disease
Devinder Singh,Rajnendrapal?aur,Vikas Chander,Kanwaljit Chopra 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.4
Reactive oxygen species (ROS) play a key role in the pathophysiological processes of renal diseases. The cel-lular damage is mediated by an alteration in the antioxidant status, which increases the concentration of ROS in the station-ary state (oxidative stress). Oxidative stress mediates a wide range of renal impairments, from acute renal failure, rhabdomy-olysis, obstructive nephropathy, hyperlipidemia, and glomerular damage to chronic renal failure and hemodialysis. Therefore,interventions favoring the scavenging and/or depuration of ROS (dietary and pharmacological antioxidants) should attenuateor prevent the oxidative stress, thereby mitigating against the subsequent renal damage.
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Yadav, Sunil,Mittal, Hitesh Chander,Malik, Sunita,Dhupar, Vikas,Sachdeva, Akash,Malhotra, Vijaylaxmy,Singh, Gurdarshan The Korean Association of Oral and Maxillofacial S 2016 대한구강악안면외과학회지 Vol.42 No.5
Objectives: We evaluated and recorded post-traumatic and postoperative neurosensory deficits of the inferior alveolar nerve (IAN) in mandibular fracture in order to identify associated risk factors. Materials and Methods: This was a prospective cohort study composed of 60 patients treated for mandibular fracture. The primary study variable was the change between the post-traumatic IAN neurosensory examination score and the score after fracture reduction. Risk factors were categorized as demographic, anatomic, fracture displacement, and treatment. Appropriate descriptive and bivariate statistics were computed. Results: Sixty patients with unilateral mandibular fracture reported within 24 hours of injury were evaluated over a one-year period. A post-traumatic neurosensory deficit was observed in 52 patients (86.7%), the percentage of which was reduced to 23.3% over the follow-up period. Abnormal postoperative neurosensory scores were significantly higher in angle fracture cases (33.3%) compared to body fracture cases (11.1%). When recovered and non-recovered neurosensory scores were compared by fracture location, 88.9% of body fracture cases showed significant recovery compared to 66.7% of mandibular angle fracture cases. Cases with less than 5 mm fracture displacement showed statistically significantly higher neurosensory recovery scores (90.6%) compared to those with more than 5 mm fracture displacement (60.7%). Conclusion: Use of a miniplate with mono-cortical screws does not play a role in increasing IAN post-traumatic neurosensory deficit. Early management can reduce the chances of permanent neurosensory deficit. Mandibular fracture displacement of 5 mm or more and fracture location were found to be associated with an increased risk of post-traumatic IAN neurosensory score worsening.
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