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RISS 인기검색어
- 검색키워드
- 저자 : Vanessa Rosse de Souza (검색결과 2 건)
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Lycopene and Tomato Sauce Improve Hepatic and Cardiac Cell Biomarkers in Rats
Vanessa Azevedo de Jesuz,Monique de Barros Elias Campos,Vanessa Rosse de Souza,Teresa Palmiciano Bede,Bianca Portugal Tavares de Moraes,Adriana Ribeiro Silva,Cassiano Felippe Gonc¸alves de Albuquerque 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.11
This study evaluated the effects of tomato sauce and lycopene on hepatic and cardiac cell biomarkers in rats fed a high-fat diet. Animals were split into five groups: control group, high-fat group (HG), high-fat tomato sauce group, high-fat lycopene 2 mg, and high-fat lycopene 4 mg. Food and water were offered ad libitum, whereas tomato sauce and lycopene (2 and 4 mg/day) were offered daily for 60 days. Body, heart, and liver weights, cardiosomatic and hepatosomatic indices, and serum parameters were also analyzed in rats. The animals' hearts and liver were processed, and cells were examined by flow cytometry. Results showed that the groups receiving tomato sauce and lycopene had lower glycemia. The serum concentration of high-density lipoprotein cholesterol, hepatic enzymes, and tumor necrosis factor-α did not change upon treatment. Tomato sauce and lycopene supplementation did not increase interleukin-1β in response to a high-fat diet. Cell cycle analysis of cardiac and liver cells showed a lower percentage of cells in the G0/G1 phase and an increase in the G2/M phase in HG. Both lycopene and tomato sauce reversed this effect. Both lycopene and tomato sauce reversed this effect and prevented high-fat diet-stimulated cardiac and liver cell death. Supplementation of tomato sauce and lycopene showed beneficial effects on cardiac and liver cell metabolism; therefore, it is suggested as a nutritional approach for the prevention and treatment of cardiovascular diseases and nonalcoholic hepatic steatosis.
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Anderson Junger Teodoro,Carolina de Oliveira Ramos Petra de Almeida,Raquel Martins Martinez,Vanessa Rosse de Souza,Thuane Passos Barbosa Lima,Bruna Almeida Nascimento,Gabriel de Alcantara Noblat,Giova 한국식품영양과학회 2024 Journal of medicinal food Vol.27 No.1
This study evaluates the effects of supplementation of murici (Byrsonima crassifolia) and tapereba´ (Spondiasmombin) pulp extracts on dietary intake, body composition, biochemical parameters, and markers of oxidative stress. Twoexperiments were conducted with a total of 80 healthy male Wistar rats and a 30-day supplementation. In the first experiment,animals were divided into control (C) group, murici group 50 mg/(kg$day) (50Mu), murici group 100 mg/(kg$day) (100Mu),and murici group 200 mg/(kg$day) (200Mu). In the second experiment, animals were divided into C group, tapereba´ group50 mg/(kg$day) (50Tap), tapereba´ group 100 mg/(kg$day) (100Tap), and tapereba´ group 200 mg/(kg$day) (200Tap). Resultsshowed lower feed intake in 50Mu, 100Mu, and 100Tap groups (13%, 12%, and 10%, respectively, P < .05) and lower bodyfat in 200Mu, 100Tap, and 200Tap groups (16.0%, 29.1%, and 27.1%, respectively, P < .05). Only the 100Tap group showedreduced adipose tissue content (30.4%; P < .05). Increased plasma antioxidant capacity was observed at all doses for bothfruits. Tapereba´ supplementation reduced ferrous oxidation–xylenol orange levels (50Tap: 8.4%, 100Tap: 16.1%, 200Tap:24.3%; P < .05) and increased thiol levels (50Tap: 39%, 100Tap: 31%; P < .05). Serum thiobarbituric acid reactive substanceslevels were reduced in all groups receiving tapereba´ (50Tap: 77.7%, 100Tap: 73.1%, 200Tap: 73.8%; P < .05) and murici(50Mu: 44.5%, 100Mu: 34%, 200Mu: 43%; P < .05). Therefore, it is suggested that the inclusion of these fruits in the diet cancontribute to health maintenance and disease prevention, through their effects on controlling food intake, improving bodycomposition, and in combating oxidative stress.
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